The Need for the Legalization of Physician-Assisted Suicide

Throughout the course of history, advances in medical technology have prolonged the length of life and delayed death; however, terminal illnesses still exist and modern medicine is often unable to prevent death. Many people turn to a procedure known as Physician-Assisted suicide, a process by which a doctor aids in ending a terminally ill patient’s life. This procedure is painless and effective, allowing patients to control their death and alleviate unnecessary suffering. In spite of these benefits, Physician-Assisted suicide is illegal in many places both nationally and internationally. Despite the fact that Physician-Assisted suicide is opposed by many Americans and much of the world on ethical and moral grounds such as those based on†¦show more content†¦In Oregon, for example, the practice became legal in 1994 but many different lawsuits and court cases delayed the implementation of the law for years. Lawsuits blocked Oregons Death with Dignity Act for three yea rs after it was passed. (DOC: Assisted Suicide). Unfortunately, voter initiatives have often blocked the use of laws allowing Physician-Assisted suicide. Over time, many states have attempted to pass laws to make Physician-Assisted Suicide legal; however, these voter initiatives have failed to pass in almost every state, with the exceptions being Oregon, Montana, and Washington. (Suicide, Euthanasia, and Physician-Assisted Suicide). Further, these initiatives have been attempted many times, such as in California, but have failed to gather enough support. (Introduction to Assisted Suicide: Current Controversies). Nevertheless, the support for the legalization of Physician-Assisted Suicide is increasing across America and may become a more widely accepted practice in the near future. (Suicide, Euthanasia, and Physician-Assisted Suicide). While support for Physician-Assisted suicide is increasing, it is unlikely that the issue will become one decided by the federal government and will remain a state issue instead. This issue, however, is not unique to the United States; it is a controversial topic in many European nations. Many European nations allow assistedShow MoreRelatedEthical Considerations in Dealing with Changes in the Healthcare System929 Words   |  4 Pagesconsideration that creates controversial discussion is the subject of physician-assisted suicide. Physician-assisted suicide is described as the act in which a physician provides the means necessary for the client to perform the act of suicide. The issue of physician-assisted suicide is viewed through many different perspectives. The topic of physician-assisted suicide has been debated since the development of medicine. Physician-assisted suicide was first legalized in the United States in Oregon in 1997.Read MoreArgumentative Essay On Assisted Suicide1101 Words   |  5 PagesAssisted suicide is a topic that has ignited a severe debate due to the controversy that surrounds its implementation. Assisted suicide occurs when a patients expresses their intention to die and request a physician to assist them in the process. Some countries like Oregon, C anada, and Belgium have legalized the process terming it as an alternative to prolonged suffering for patients who are bound to die. Unlike euthanasia where a physician administers the process, assisted suicide requires thatRead MoreSince The Fifteen Century, Society Has Viewed Suicide Or1178 Words   |  5 PagesSince the fifteen century, society has viewed suicide or intentional death as immoral. It was not until the twentieth century that these â€Å"immoral† attitudes were challenged. As of 2016, the Netherlands, Belgium, Luxembourg, and Colombia have unambiguously legalized direct assisted dying. Other areas, having to undergo a process of either a judicial or legislative decision, include Canada, Japan, and Germany. Currently in the United States, following the same process of a judicial or legislative processesRead MorePhysician Assisted Suicide Should Be Legalized1487 Words   |  6 Pagesthat physician assisted suicide should be legalized in the case of a chronic i llness, where the patient must take a large amount of drugs to heal themselves and or to subdue pain, and where the patient is living a life that is less fulfilling, or diluted, from their life before. Physician assisted suicide can be to patients who are suffering and wish to end their life, with the help of a physician so the patient could feel more comfortable or safer. As mentioned in class, physician assisted suicideRead MoreAssisted Suicide And The Death With Dignity Act803 Words   |  4 PagesIntroduction Physician-assisted suicide (PAS) occurs when a physician facilitates a patient’s death by providing the necessary means and/or information to enable the patient to perform the life-ending act (e.g. the physician provides sleeping pills and information about the lethal dose, while aware that the patient may commit suicide). [Carter, 2015]. According to Death with Dignity.org, Oregon, New Mexico, Vermont, Washington and California along with Montana who administrated the Death with DignityRead MorePros And Cons Of Assisted Suicide1743 Words   |  7 PagesWhat is assisted suicide? Merriam-Webster lists assisted suicide as â€Å"suicide committed by someone with assistance from another† (Assisted Suicide, n.d.). Particularly by a licensed health care provider/physician willing to participate and authorized by the state. The physician will assist with, in administering an approved prescription drug and a lethal dosage. Assisted suicide acts upon the legal request and appr oval of state law and patient request for the reasons of a terminal condition in orderRead MorePersuasive Speech : Physician Assisted Suicide1308 Words   |  6 PagesCheyenne Jamison 4/19/17 Persuasive Speech Outline Topic: Physician Assisted Suicide Specific Purpose: To persuade the audience to favor the legalization of Physician Assisted Suicide. Thesis: Physician Assisted Suicide is sometimes misunderstood due to how it is termed, but this is something that needs to be deeply evaluated and legalized in all 50 states. I. Introduction: A. Attention Material/Credibility Material: The John Hopkins News-Letter said in 2014 â€Å"What would you do if you only hadRead MoreThe Ethics of Euthanasia Essay1742 Words   |  7 Pagesmisery, however in the state of North Carolina, physician-assisted suicide is illegal. Luckily, her father passed away this year and is finally free of pain and suffering. However, if physician-assisted suicide was legal, her father would not have had to suffer as long as he did. Before we explore the sides of physician-assisted suicide, let’s go over exactly what physician-assisted suicide entails. When the topic of physician-assisted suicide comes up, many individuals believe it is the sameRead MoreLegalizing Assistive Suicide1278 Words   |  5 PagesAssistive suicide, also known as euthanasia, â€Å"is suicide committed by someone with assistance from others, typically to end suffering from a severe physical illness† (American Heritage Dictionary, 615). This action is most commonly committed between doctor and patient interactions. This controversial issue depicts suicides as a helpful solution to personally benefit terminally ill patients, as opposed to a forbidden social issue. Assistive suicide has become a major debate of legalization. â€Å"This isRead MoreEuthanasia And Assisted Suicide Should Be Legalized Essay1221 Words   |  5 Pagesco-authors of â€Å" Why active euthanasia and physician assisted suicide should be legalized † suggest that active euthanasia should be legalized because it can end a patient’s suffering, there is not much of a difference between the passive and active euthanasia, and it gives the patient a choice. In the article,â€Å"Why active euthanasia and physician assisted suicide should be legalized†, Len and Lesley Doyal argue that active euthanasia and physician assisted suicide should be legal in medical practices;

John F Kennedy And Richard Nixon - 1612 Words

In our nation, the power of Democracy is our greatest power. The job as a citizen is to elect representatives to keep in contact with our personal liberties and create equal power in governing for all. During the 1960 election, John F Kennedy and Richard Nixon created what is known as the First modern campaign. In the book, â€Å"The First Modern Campaign†, by Gary A. Donaldson, he discusses some of the struggles Kennedy had to go through in order to come out on top. The fact that Kennedy was not a liberal made it very hard at first to win over any votes. In the Textbook, â€Å"American Government, Roots and Reform†, it stated that a liberal is, one who favors greater government intervention, particularly in economic affairs and in the provision of social services. In previous history, Kennedy, has completely gone against the liberals and has supported communist activities. Kennedy knew, however, that he would not win the election without the support of the liberals. (3 9) Kennedy tried many ways to appeal to the people of the united states, however, his competitors seemed to always have an upper hand. Until Humphrey came along during the primaries and Kennedy could portray himself as the underdog. Humphrey never had a lot of votes, but as time went by the money for his campaign lessened and he later described it as, â€Å"money for a campaign is as basic as gasoline for a motor, if you run out, the vehicle stops.† (49) While touring Wisconsin during the primaries Kennedy’s religion cameShow MoreRelatedThe Presidential Debates Between John F. Kennedy and Richard Nixon1524 Words   |  7 PagesThe Presidential Debates Between John F. Kennedy and Richard Nixon In the Presidential Election of 1960 John Fitzgerald Kennedy and Richard Milhouse Nixon were in a series of debates that were different from past debates. The three biggest national television networks arranged for the debate to be televised on all three stations. The Democratic candidate, Senator Kennedy from Massachusetts, and Vice President Nixon both agreed on the televised debates. Each debate was given a subjectRead More1960 Presidential Election: Richard Nixon vs. John F Kennedy2667 Words   |  11 Pagesï » ¿President Election 1960: Richard Nixon v. John F. Kennedy The 1960 Presidential Election was historic in its new approaches to media and televisions ability to capture the future leader of America live for the first time. Previous presidents had been listened to via radio, and seen in retrospect in movie theaters, particularly during World War II, but 1960 was the first time the majority of Americans were able to watch their future President debate his opponent and feel the immediate reactionsRead MoreThe First Televised Debate Between Richard Nixon And John F Kennedy936 Words   |  4 Pagesevent that kicked off the 1960s was the first televised Presidential Debate between Richard Nixon and John F Kennedy. This debate changed the way the American populous approached politics because it allowed anyone with a television to have a front row seat to the debate. Furthermore, when individuals listened on the radio, the thought that Nixon had better answers, but when citizens saw how composed John F Kennedy was, they believed that he had one. Also, the event that closed the 1960s was theRead MoreEssay on The Watergate Scandal1270 Words   |  6 Pagespresident Richard Nixon re election campaign, and they were caught trying to wiretap the phones. The robbers who tried to wiretap the phones were not successful. more robbers broke into the Watergate building with a new microphone, but a guard noticed that they broke the locks on the doors. The guard called the police as soon as possible, they showed up and caught the crooks red handed and took the to jail. it was not completely clear that the crooks were connected to the president Richard Nixon. ThereRead MoreBiography Of John F. Kennedy Essay1644 Words   |  7 Pagesboth candidates Republican Richard Nixon and Democrat John F. Kennedy. Nixon and Kennedy were polar- opposites when it came to politics and even their personalities were distinct. John F. Kennedy was young and charismatic whereas Nixon was more traditional with his ways of running his campaign. John F. Ke nnedy prevailed with his ability to manipulate the press and use his money in ways other candidates have never been able to do before. Born to Joe and Rose Kennedy, John was one of four sons thatRead MoreJohn F. Kennedy: A Legacy Never Forgotten1377 Words   |  6 Pages Forgive your enemies, but never forget their names(Brainy Quotes). John F Kennedy said this during one of his speeches, and ironically no one will ever forget the name of the person who murdered him, Lee Harvey Oswald, an enemy of the American Public. When Kennedy ran for office, he had to seem like the more experienced candidate and appeal to all of the people. During his speeches, Kennedy engaged his audiences and they hung on his every word. However, the tragic event of his assassinationRead MoreJohn F. Kennedy s Accomplishments Essay1532 Words   |  7 PagesIn the end, John F. Kennedy, the Democratic nominee, had only been elected by a one-tenth of a percent margin against his Republican party opponent, Richard M. Nixon. John F. Kennedy had made specific decisions as the Democratic candidate that helped him leap to victory. Specifically, JFK’s performance during the first televised debate, decision to focus on key large states, Houston tape, and other decisions had overall led to him winning the election of 1960. On the other end, Nixon had made someRead MorePresidential Debate Over Presidential Debates947 Words   |  4 Pagesthrottle, Kennedy and Nixon’s presidential debates of 1960 are still very much a part of American democracy. Televised presidential debates have become a backbone in an American election. Although these debates are now considered a norm in American politics, this has not always the case. Even after the first time a presidential debate was held between presidential candidates from across the aisle, it took another 16 years for another debate to occur. It is highly doubtful that either Nixon or KennedyRead MoreDo Public Debates Help Or Hurt Candidate Success?868 Words   |  4 PagesSenator John F. Kennedy and Vice President Richard Nixon was about to partake on an adventure that was ordinary. On that night, one of the most legendary moments transpired. This moment increased the power of television and benefited e lectioneering since the political button on a shirt. The Nixon-Kennedy encounter had all interest, with the nation watching the first televised presidential debate. For a majority of the United States of America, it was their first presentation of John F. Kennedy. WhenRead MoreKennedy-Nixon Debate Analysis779 Words   |  4 PagesProfessor Fernando Ganivet SPC 3540 – Persuasion October 22, 2013 Kennedy-Nixon Debate Analysis There may be more truth to the old saying, â€Å"it’s not what you say but how you say it.† On average, 93 percent of meaning found in communication comes from nonverbal messages (Mehrabian 1967). Nonverbal communication is the wordless transmission of information through body language, gestures, tone, space and appearance. The first televised presidential debate is a pivotal example of how pervasive

Acer’s North American market Free Essays

Acer’s North American market share has slipped over the past few years, while in contrast, the company’s European market share has risen. [8] In the mid-2000s years, consumer notebooks have been almost the sole growth drivers for the PC industry, and Acer’s exceptionally low overheads and dedication to the channel had made it one of the main beneficiaries of this trend. [9] Acer grew quickly in Europe in part by embracing the use of more traditional distribution channels targeting retail consumers when some rivals were pursuing online sales and business customers. We will write a custom essay sample on Acer’s North American market or any similar topic only for you Order Now In 2007 Acer bought Gateway in the USA and Packard Bell in Europe and became the Number 3 world provider of computers and number 2 for notebooks, and achieved significant improvement in profitability. Acer has been striving to become the world`s largest PC vendor, in the belief that the goal can help it achieve economy of scale and garner higher margin. [10] But such a reliance on the high-volume, low-value PC market made Acer exposed when buying habits changed. On June 2011 Acer re-evaluated its inventory-management strategy in light of worsening economic conditions in Europe, clarifying a large write-down. Acer said the main reason for the disputes was â€Å"high inventory† carried by distributors of its products, reflecting an â€Å"inappropriate strategy† in its European operations under the current market situation. In a written response to questions from The Wall Street Journal, Acer said â€Å"Southern Europe’s economic situation has been worsening since last year† and the stagnant technology market, particularly in Spain, â€Å"influenced Acer’s PC sales†. Acer discovered the problems through a routine audit, it added How to cite Acer’s North American market, Papers

Health Information Management for Korzybski- myassignmenthelp

Question: Discuss about theHealth Information Management for Korzybski. Answer: Medical records are important to healthcare staff and physicians to learn in a short time the patients medical care history. This enables them to understand current diagnosis, prior care so as to be able to come up with a treatment plan for the patient. In patient care, clinicians deem medical records as vital tools. They contain patients self reported information, diagnoses notes from physicians, care, lab tests, biographical data, other medical conditions, preventive therapies and earlier treatments. Therefore, these records help clinicians to know where the patient is going by understanding where they have been. It acts as a roadmap in the patients treatment more so to subsequent physicians to provide the best possible care to the patient. The long standing views of Korzybski that the map is not the territory and the representation of reality is not reality itself are not legitimate in this situation because the patients medical records represent every bit of the medical condition the patient is in. It is this records that are used to formulate a treatment plan for the patients. Therefore, whatever is in the medical record is legitimate otherwise patients could not be getting better from their ailments after treatment. Medical records contain the reality of a patients illness. The information recorded is gotten from past records, diagnosis, observations and lab tests making it real. Medical records do not just embody patients medical history but also forms a basis for treatment. Contemporary medical records are meant to aid cognition, create a comprehensive and continuous account of care, communicate and support the patients long term care. They help in creating medical decisions and relationships and at the same time decrease workload. Documentation of Medicare is overtaking care delivery in terms of perceived importance, clinician focus and time. Medical records are used to provide evidence to backup patient care aspects and for evaluation purposes to enhance the services quality. The records have been used for research to improve, guide performance, as a legal record and support making of decisions. All these uses tend to shift clinician attention more to appropriate record keeping other than focusing all the attention to patient communications and narratives. Medical records use in reimbursement policy coarse providers to document services legibly, accurately and completely for the third parties that are mostly insurers. This increase the lengthy of the records in HIMs in a bid to communicate to set standards by insures which in providing care services are not helpful. However, these should be done to enable claims settlement easy even though it strains service providers. Concerns of compliance and time constrai nts have created poor documentation as a current monster in medical records; however it can be easily solved by eliminating the causes. References Bleich, H. L., Slack, W. V. (2010). Reflections on electronic medical records: when doctors will use them and when they will not. International journal of medical informatics, 79(1), 1-4. Boonstra, A., Broekhuis, M. (2010). Barriers to the acceptance of electronic medical records by physicians from systematic review to taxonomy and interventions. BMC health services research, 10(1), 231. Chapnick, P. (1989). The Map is Not the Territory. ETC: A Review of General Semantics, 352-354. Leung, R. S. (2013). The map is not the territory. Urbanik, B. A. (2012). The Map is Not the Territory (Master's thesis, University of Waterloo).

Alice and Coraline Essay Example

Alice and Coraline Essay Austin Way English I Mr. Keiter February 28, 2013 Alice and Coraline Comparison The book Alice in Wonderland was written by Lewis Carroll. Coraline was written by Neil Gaiman. Each book was later turned into films to help better get a picture of the adventurous lands the girls traveled through. In the movies Alice in Wonderland and Coraline there are many similarities but also many differences. Though having many differences and similarities each film taught a lesson to the audience by showing the interesting journey of each girl and their adventures along the way. There are many similarities between the movies. In both stories the viewpoint figure meets a talking cat. The girls were around the same age during their adventures. They both went forward into a different reality due to their curiosity. When they arrived to this unknown place it was cool and interesting to them. They both went through a hole to get to this opposite/wonderland. They each started out pretty much unhappy with the way their life was. They both returned with a new sense of life. Both were in danger by a female dominate figure (Queen of hearts/Other Mother). Alice was uncertain about all that was happening around her. Coraline adored the change at first. Alice was set up more colorful and strangely cheery. Coraline was gothic looking and dark. Coraline had to help the souls of other girls who had fallen to the Other Mother, Alice didn’t. Alice grew and shrunk throughout the book/film, while Coraline stayed the same. In Alice in Wonderland Alice follows a talking white rabbit down a hole. We will write a custom essay sample on Alice and Coraline specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Alice and Coraline specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Alice and Coraline specifically for you FOR ONLY $16.38 $13.9/page Hire Writer In this hole is where her journey begins. Alice must kill Jabheiwoki to return to her normal life. Sadly when Alice returns home her family is the same. Though upset things haven’t changed Alice is now strong enough to stand up to her fiance that she doesn’t want to get married to. â€Å"Alice† is mostly a book without a plot telling of Alices dream experiences which don’t particularly make sense but are not supposed to make sense. It is a dream tale. Alice herself is the viewpoint character and as such is very â€Å"normal†. Alice seems no different in â€Å"Through the Looking Glass and What Alice Found There†. Coraline is also the viewpoint character and very normal, but the events that happen to her, within the story, are supposed to be â€Å"real†, not a dream. In Coraline she also enters another world because her family doesn’t pay attention to her. She must trick and kill the other mother to return to her real life and get out of this button fancy. Coraline also saves her real family in the fancy land. When they return to real life the family is much closer and has a stronger relationship. Coraline† has a plot in which a mysterious spidery woman is attempting to persuade Coraline into remaining in this other world forever. No such temptation is ever laid before Alice. In Coraline others have previously been taken captive by the ruler of the world in which Coraline finds herself which is a plot element the like of which does not exist in â€Å"Alice†. Coraline must rescue them. â€Å"Alice† has some characters appear more than once, for example, the Duchess, the Cheshire Cat, and the Hatter but nothing that corresponds to a main plot. Coraline gets out of the clutches of the spidery woman by being clever. Alice gets out of her dream by just waking up. Coraline must crawl back through the hole after killing the other mother. Alice does not change in the story, or at least we are not shown enough of what she was like before the dream or after to see what kind of change in her personality may have occurred. Coraline changes and becomes happy for what she had but is also grateful that this whole experience brought her and her family closer. This was a big difference in the movies because this showed the message the author was trying to send to the audience. If the Queen of Hearts is compared to the spidery woman, it will be observed that they are quite different. The Queen of Hearts seems to be brutal but the reader is told that the many beheadings she orders never actually occur and that we are shown that the King pardons the poor gardeners. The Queen, like most characters in the story are mad, but she is being coddled and protected in her madness. The spider woman, on the contrary, is a force to be reckoned with and has real power. Later both girls realized it was just a front and the places become scary. Each girl then finds themselves fighting to get back home to their normal lives. The adventures, though scary, changed the lives of the young girls. They both became stronger in who they were. Although the girls weren’t very happy with their real life before their journeys, they were still happy to be home. They both learned something or became a stronger individual. Though they were scared during their journey, something good comes from everything bad. The girls learned to appreciate what they had and to be careful what they wish for.

Here Are Six Tips for Reporters Covering Press Conferences

Here Are Six Tips for Reporters Covering Press Conferences Spend more than five minutes in the news business and youll be asked to cover a press conference. Theyre a regular occurrence in the life of any reporter, so you need to be able to cover them - and cover them well. But for the beginner, a press conference can be tough to cover. Press conferences tend to move quickly and often dont last very long, so you may have very little time to get the information you need. Another challenge for the beginning reporter is figuring out the lede of a press conference story. So here are six tips for covering press conferences. 1. Come Armed with Questions As we said, press conferences move quickly, so youll need to have your questions ready ahead of time. Arrive with some questions already prepared. And really listen to the answers. 2. Ask Your Best Questions Once the speaker starts taking questions, its often a free-for-all, with multiple reporters shouting out their queries. You may only get one or two of your questions into the mix, so pick your best ones and ask those. And be ready to ask tough follow-up questions. 3. Be Aggressive If Necessary Any time you get a bunch of reporters in one room, all asking questions at the same time, its bound to be a crazy scene. And reporters are by their nature competitive people. So when you go to a press conference, be prepared to be a bit pushy in order to get your questions answered. Shout if you need to. Push your way to the front of the room if you must. Above all, remember - only the strong survive at a press conference. 4. Forget the PR Speak - Focus On the News Corporations, politicians, sports teams and celebrities often try to use press conferences as public relations tools. In other words, they want reporters to put the most positive spin possible on whats being said at the press conference. But its the reporters job to ignore the PR talk and get to the truth of the matter. So if the CEO announces that his company has just suffered its worst losses ever, but in the next breath says he thinks the future is bright, forget about the bright future - the real news is the huge losses, not the PR sugarcoating. 5. Press the Speaker Dont let the speaker at a press conference get away with making broad generalizations that arent supported by facts. Question the basis for the statements they make, and get specifics. For instance, if the mayor of your town announces he plans to cut taxes while at the same time increasing municipal services, your first question should be: how can the town provide more services with less revenue? Likewise, if that CEO whose company has just lost billions says hes upbeat about the future, ask him why - how can he expect that things will get better when the company is clearly in trouble? Again, get him to be specific. 6. Dont Be Intimidated Whether youre covering a press conference with the mayor, the governor or the president, dont let yourself be intimidated by their power or stature. Thats what they want. Once youre intimidated, youll stop asking tough questions, and remember, its your job to ask tough questions of the most powerful people in our society.

Entrepreneurship Case study Essay Example | Topics and Well Written Essays - 1750 words

Entrepreneurship Case study - Essay Example The most obvious reason for branding him as one is that he sought and recognized an opportunity in the niche market took a risk and organized his resources (Harper, 2003; pp 10). He realized that ladders were used in everyday setting thus he created a set of rails that went attached to the ladder would increase the safety levels. This was a new product that is handled well would transform into a profitable venture. By so doing, he hoped to attain financial freedom and provide a better life for his family. He is an entrepreneur as he was future oriented and had a vision that by investing in his business venture, his financial status would be improved and he would spend more time with this family. The only way one can determine his future is by investing in it. He was willing to sacrifice in the short run to reap benefits in the long run. He spent time in developing an idea that had never been tried before but this did not mean that it could not be achieved (Harper, 2003). Sid mobilize d at his all the capital resources at his disposal due to his innovative nature. The general blueprint of his entrepreneurial strategy was rather simple and centralized as Sid wanted to simply sell his product to the local market as he had previous interactions with them (Economic Expert, 2008). Sid Stevens was market driven and was well aware that his success was pegged on the satisfaction of his customers. He was ready to modify his approach to be synonymous with the market demand when there was a demand for different rail specifications. He also managed to create employment and this had an impact on the economy in the long run due to the accelerator and multiplier effects on the economy. Sid Stevens was committed to being the best in his venture and his frustration with his employees on their compromise on quality was unending. He has a strong sense of business ethics that guided his desire to provide quality products. Despite the challenges and frustrations, his resilience in the pursuit of success was undeterred. Initially, his wife, the banker and his former employer expressed their skepticism on the viability of the project. However, Sid's optimism on the possibility of what the future held saw him remain true to his cause (Knight, 1967). Once it took off, he was a f ocused and effective decision maker as any delay in the decision making process will compromise the business. QUESTION 2: The Beermat Entrepreneur notes that four cornerstones are necessary for an entrepreneurial endeavor to succeed. What cornerstones did the Ladder Rail venture have, and which were missing What could Sid have done to fill in these gaps in his business The Beermat entrepreneur demands that ha potential entrepreneur profiles himself so as to determine if one should embark on an entrepreneurial venture or to team up with an actual entrepreneur as a corner stone of a new company or as a member of the dream team of a more established company. A cornerstone is an individual with expertise in certain business areas such as management, leadership, public relations, recruitment, marketing and finance. The four cornerstones according to the Beer Mat entrepreneur are involved in finance, technical operations, business' sales and delivery. These individuals are instrumental in the overall well being of the company as they have the technical know how to deal

Public Relations Situation Assignment Example | Topics and Well Written Essays - 1000 words

Public Relations Situation - Assignment Example They could also sound offensive depending on choice of words used in relation to the culture of the target audience. It should be noted that cultural diversity encompasses differences in language, religion, beliefs, social aspects, race and ethnicity as noted by Chia and Synnott (2009). Some of these factors are easy to change and some are not. This means that the public relations professionals should be able to adjust to the cultural aspects of the various audiences of an organisation. Grunig and Toth (2006) explain that they should be able to demonstrate an awareness, understanding and sensitivity to their cultures and interactions between the various cultures. It should also be noted that the audience in public relations are more fluid and this requires adequate response to this. This can only be achieved if there is sufficient flexibility among public relations to adapt to a changing world. Effective public relations professionals or departments are those that have recognised and acknowledged the important fact that discrimination is unhealthy for business. They should also have recognised the importance of taking advantage of a multi-cultural communities and how fast this opportunity is growing. Hain (2008) points out that if public relations professionals or departments were to realise this, they would be able to enable their firms or clients to exploit the cultural diversity in their society or target region. As noted in the introduction, situation analysis is where an organisation evaluates the main communication issues it faces. An awareness in cultural diversity increases the competency of public relations practitioners to note these issues and advice organizations on how to respond... The paper makes a conclusion that each organisation has its own expectations, values and beliefs that shape its public relations. Cultural awareness among public relations practitioners is therefore important in ensuring that the messages they give about the organisation responds to cultural diversity while maintaining consistency with the beliefs, values and expectations of the organisation. For example if organization believes in and values a diverse workforce, then the organisation’s public relations department will have more authority to include practitioners from varied backgrounds and standpoints. The paper approves that multicultural awareness increases the professional relevance of public relations practitioners. It also markets them due to increasing demand by many companies to appeal to the local and global multicultural communities. The paper describes the main thing behind variations in culture is differences in perspectives leading to differences in preferences. This makes cultural awareness a critical competency among public relations practitioners and the public relations department personnel. The awareness of cultural diversity increases the professional relevance of public relations practitioners because of the increasing diversity both in the local and international communities. In order to gain a competitive advantage and increase their market shares, public relations firms takes advantage of the growing cultural diversity and targets or hires people of immigrant origin.

Prompt 4 Coursework Example | Topics and Well Written Essays - 1000 words

Prompt 4 - Coursework Example The movement has been enhanced by the requirement in the US that every employee who has more than 50 employees should seek health insurance cover for his/her employees. It is estimated that half Americans that is an approximate 170 million people are covered by employer-sponsored health insurance which was as per thee census data taken. The Obama administration is not willing to make any delay on the implementation of the Obamacare’s employer mandate where it has established that all firms should cover their employees offer health coverage or pay fines until 2015.Connectively, having prepared the rolling out of the private health insurance, ObamaCare, and the overall federal state economy. According to researchers, the delay of the mandate will have more people to enroll in the Obamacare’s subsidized insurance exchanges due to shared responsibility payments (Getzen, 2010). Additionally, if the rolling out is delayed the drive may raise the cost of labor, therefore, increasing unemployment. The employers are willing to be spared the mandate for one more year. Politically the democratic are not willing to have the promise they made to the citizen be not fulfilled before their time on office comes to end. Additionally it is also argued that health that the US health- care system is mostly the tax codes that have people covered through their employers instead of shopping for their own cover. Nevertheless economist has stressed that it is better for a collective buy which could be easy done by the employer that individuals since it is much cheaper and easy to manage through their salaries. The plan estimates that about 96 of employers will be subjected to the responsibility of covering their employees (Getzen, 2010). Since enough time has been allowed for the companies to consider simpler ways that they are expected to do their reporting as

Enterprise Resource Planning System for Insurance Sector

Enterprise Resource Planning System for Insurance Sector The Indian Insurance industry is a flourishing one which has several national and international players who compete for excellence. With several reforms and policy regulations, the Indian insurance sector has witnessed tremendous growth in the recent past. India having around 17% of the worlds population is a largely untapped market. Nearly 80% of the Indian population being without a life, health and non life insurance, a growing number of insurance companies are now emerging in the Indian insurance sector. With the opening up of the economy, several international leaders in the insurance sector are trying to venture into the India insurance industry. The growth in the insurance industry directly impacts the reinsurance industry. Reinsurance providers are basically companies that provide insurance cover to insurance companies so as to cover their risk. With the growth in the amount of insurance products sold by the insurance companies their risk component goes on increasing. So as to cover this risk, companies resort to reinsurance. Thus the reinsurance market is all growing at a rapid pace. The growth of the Reinsurance industry in India is coupled with a number of challenges. Challenges faced by the reinsurance industry include shrinking margins, increasing competition etc. In order to meet the challenges, reinsurance companies across the globe have begun leveraging heavily on their information and communication technologies. Reinsurance firms are using enterprise management solutions to increase productivity, save on expenses, to obtain higher customer satisfaction, thereby resulting into customer retention and to improve sales performance. General Insurance Corporation of India (GIC Re) is the sole reinsurance company in the domestic reinsurance market in India with more than three decades of experience in the Re-Insurance business. GIC is headquartered in Mumbai. In India, GIC provide reinsurance to the direct insurance company as it is the sole reinsurer in the market of domestic reinsurance. It is one of the leaders in the facultative placements and domestic companies treaty programmes. OBJECTIVES FOR ENTERPRISE RESOURCE PLANNING SYSTEM The key objectives for initiating ERP implementation were as follows: So as to retain leadership position in the national (Indian) reinsurance market. The intention of emerging as the leader of reinsurance in the Afro Asian markets. To obtain an integrated view of all business transactions. MAJOR BUSINESS CHALLENGES FACED BY GIC RE Customer-Centricity The change in focus of the organization to being customer-centricity created a number of issues for the company. It became important to have optimal knowledge of all the customer segments. Customized products and services were required to designed to meet the needs of each of the identified customer segments. It became important to adopt cross selling of products and services as an important growth strategy. It also became important to provide any time and any place reachability to the customers. Competition The growing number of players in the market created an environment of intense competition In order to sustain such levels of competition it became imperative for the company to adopt new strategies and identify means of securing a competitive advantage over its competitors. Globalization Expansion of company operations across multiple geographical locations also made it necessary for GIC Re to identify means of effective monitoring and control. Expansion also increased the level of competition by adding new competitors from the new geographical locations. Product Commoditization The increase in competition was impacting the companys profit margins. It became absolutely necessary for the company to distinguish its brand from competitors. Lower customer loyalty and increasing price sensitivity were also measure threats to GIC Re. Consolidation It was important to bring about a consolidation across the organization so as to deliver a clear value to its customers. Compliance Expansion of operations across multiple geographical locations made its imperative to comply with multi-national regulations. MAJOR IT CHALLENGES FACED BY GIC RE Data Quality Data maintained by the organization was fragmented by the line of business, the branches, the different geographical locations etc. It was important to consolidate this data and provide high quality of product and operations related data. Process Integration It was important to standardize and streamline cross functional processes and develop and integrated workflow. The company was suffering from value leakage due to non integration of systems. Legacy IT Systems The legacy system used by the company did not reflect the change in focus from being a contract centric to customer centric insurance provider. Reduction of Operation Complexity The company used a number of applications to manage the daily activities. As a result, a number of interfaces had to be monitored and managed which proved to be very difficult. It thus became important to reduce the number of interfaces and bring about standardization across the interfaces. EXPECTATIONS FROM ERP Reduction in overall cost through improved efficiency and increased productivity Drive business innovation To a give a competitive advantage to the company over its competitors Driver for business growth Improve overall customer experience and satisfaction Ensure regulatory compliance Support global operations Create new revenue streams for the company Ensure growth of existing revenue streams CHOICE OF SAP The major factors contributing to the choice of SAP are as follows: Integrated Enterprise platform for transacting GICs business The company required a platform that would integrate all the processes and procedures across the enterprise. The system was required to standardize all processes and streamline set of processes across the organization rather than streamlining large number of procedures. The company expected the have an enterprise wide visibility of business operations. SAP Reinsurance solution being used by Global Industry leaders Munich Re and Hannover Re One of the major contributing factors to choosing SAP was the companys biggest competitor and the global industry leader Munich Re and Hannover Re had implement SAP Reinsurance system. Adoption of the global best practices By 2005, SAP Insurance had almost all insurance service providers running it. SAP had in the past implemented both the insurance and reinsurance packages for multiple clients. This enabled SAP to gain an understanding of the global best practices in the prevalent in the industry. GIC Re hoped to reap the benefits of this knowledge in their own implement of SAP Reinsurance. Most companies who had previously implemented ERP had strong positive experience with SAP for their insurance portfolio ERP IMPLEMENTATION START DATE Early 2005 ERP GO LIVE DATE February 2006 SAP VERSION SAP R/3 Version 4.7 GEOGRAPHICAL SCOPE Offices in India, London and Dubai SAP MODULES IMPLEMENTED SAP FS-RI Reinsurance SAP FS-RI is an insurance solution that enables reinsurance firms, direct insurers and brokers to achieve a reinsurance process that is completely integrated and streamlined. SAP FS-CD Collections / Disbursements SAP FS-CD is a solution designed for insurance service providers to standardize and streamline their billing and disbursement activities for their policyholders and agency holders. SAP IM-IC (CFM) Investment Management SAP IM-IC (CFM) module provides useful tools for reporting of WBS which are in progress, PO commitments and assets that have been capitalized. SAP FI-CO Finance The SAP FI-CO module can be viewed as the core of the integrated SAP system as it deals with the monetary impacts on business and other modules of SAP. SAP HR Human Resources SAP HR is the largest module implemented It deals with the management of human resources and human capital SAP BIW Business Intelligence SAP BIW is the business intelligence module that provides analytical, reporting and data warehousing solution IMPLEMENTATION CHALLENGES First SAP Reinsurance (FS-RI) implementation outside Europe. First SAP FS-CD Implementation in India. First SAP IM-IC implementation in India in an Insurance/Reinsurance environment. One of the few Active Reinsurers in the world using SAP FS-RI Legacy data Migration Customisation of Reinsurance Module (FS-RI) Risk Manager in FS-RI (Facultative Business) had not yet been implemented even in Europe IMPLEMENTATION HIGHLIGHTS Opportunity to critically re-look the companys business processes and practices and incorporate changes wherever required. Elimination of data inconsistency by correcting, validating and cleansing legacy data. Opportunity to streamline the organisation by adopting the global best practices in the industry BUSINESS BENEFITS Tight integration between underwriting and technical Accounting processes thereby providing better business focus. Integrated processes eliminating almost all redundancies and inter-departmental reconciliations. Increased automation reduced manual intervention and improved data quality. Improved reserving process (tracking the development of outstanding loss reserves). FINANCIAL STRATEGIC BENEFITS SAP allowed visibility of all assets Standardized evaluation of all assets were achieved Daily updates to the investment portfolio enable the company to achieve integrated investment management Effective real time risk analysis TOTAL COST OF OWNERSHIP 95 % of the companys requirements were met by th standard solution offered by SAP and minimal customization was required OPERATIONAL BENEFITS The operation benefits as evaluated by the company after two years of implementation are as follows: KEY PERFORMANCE INDICATORS (KPI) IMPACT Time to measure performance -70% Time to plan for new projects and activities -30% Time to performance market risk analysis -80% Efforts to map sources of risk -80% Reporting Flexibility +90% Quality of Reports +80% Quality of Portfolio evaluation +90% Quality of transaction mapping +90% FUTURE PLANS Up gradation from SAP R/3 Version 4.7 to SAP ECC 6.0 platform Connecting offices in Moscow, Malaysia and South Africa to the upgraded ERP network General Insurance Corporation of India has derived significant benefits from implementation of SAP Reinsurance. From this case it is evident that SAP has the potential of being a measure source of improved efficiency and competitive advantage for insurance service providers. APPENDIX [1] Monitor Performance: Executive Dashboard [2] CEO Dashboard [3] Sales Dashboard

JAPANESE AND GERMAN WARFARE :: essays research papers

JAPANESE AND GERMAN WARFARE   Ã‚  Ã‚  Ã‚  Ã‚  The Germans and Japanese were working on taking over the World in the Second World War and had it not been for the intervention of the allied nations, they very well could have picked off the nations one-by-one until a worldwide settlement was established. The Americans would not have entered the war if Germany would have stayed within it’s own compounds. The Nazi party possibly could have survived, although the German citizens would have eventually tired of Hitler’s ideas. The problem was the extermination of citizens and taking over of other national territory. The Japanese could have possibly had a few properties in the Pacific without the United States’ intervention had they not bombed Pearl Harbor. The problem with both of these countries was that they were practicing a total takeover of the world, which has lead to post-World War II doctrine that no nation will force the takeover of another nation. Prior to the 1900s, the rest of the wor ld probably would not have taken a second look at the Iraqi takeover of Kuwait, but it is seen now that this policy will lead to further actions.   Ã‚  Ã‚  Ã‚  Ã‚  The Germans sought to gain back some recognition that was lost in the First World War, and the Nazi party promised that status. Many good things have come out of Germany, like the satellite technology that spawned the Corona Projects and eventually moved the United States ahead in the â€Å"Space Race†. But the Total Warfare policy is what forced the allied intervention and also the reason why the United Nations moves to oversee and limit warfare today. The method of the total extinction of all opposition can not be tolerated, and although Clausewitz taught us this method of war, it must be limited because if practiced to the end, there will be no opposition for a political agreement.   Ã‚  Ã‚  Ã‚  Ã‚  The Imperial Japanese were a country behind the times. The allied global forces that are now in control will not allow for another â€Å"Alexander the Great† or â€Å"Julius Ceaser†. The world now has grown into one organization, well almost one. The frontiers of the mankind are no longer the sea, the other side of his known land, or even the skies for that matter; and most of the world, at least most of the free-trade world, finds it of great economic value to avoid war.

Life Limiting Illness Essay

Sam (name changed to protect confidentiality) is a nine month old boy who was born at 26 weeks and diagnosed with chronic lung disease. He was sent home on 0.3 litres (L) of oxygen per minute with the view of gradually weaning this down as he grew stronger. When I joined the community nurse visiting Sam at home, he had been weaned down to 0.1L of oxygen per minute, so was now having his time on oxygen weaned down; from continuous oxygen eventually to none. The community nurses follow the trust’s nursing assessment guidelines which are based on The Twelve Activities of Daily Living (Roper et al, 1983). This model allows nurses to organise and prioritise care effectively for each individual child (McQuaid et al, 1996). As Sam was recovering from chronic lung disease, his respiratory well-being was the main priority. During the weaning process the community nurses conduct regular respiratory reviews to ensure Sam is coping with the lessening amount of oxygen. This assessment can begin as soon as the nurse enters the home. We were able to assess Sam’s work of breathing by looking at him and listening to him. He was not exhibiting any signs of respiratory distress such as nasal flaring, recession, grunting or wheezing, all of which would tell us he was making excessive respiratory effort (Huband and Trigg, 2000). It is essential to monitor oxygen saturations and vital signs in a respiratory review. The pulse oximeter is used to alert nurses to potential hypoxaemia. It does this by emitting red and infrared light from the sensor into the patient. Oxygenated and deoxygenated blood absorb different amounts of infrared light, so an average value can be calculated to show the percentage saturation (Huband and Trigg, 2000). The nurse ensured Sam’s foot was warm before attaching the probe to it, to determine if he had good peripheral perfusion. This is important for obtaining an accurate reading. The nurse informed Sam’s parents that we would be happy with Sam saturating above 95%. He was sitting around 99-100%, which was a great sign. His respiration rate was within limits at 41. Sam was currently having 8 hours off oxygen per day and this review showed he was coping well. The pulse oximeter also recorded his heart rate at 124 beats per minute, he was peripherally warm to the touch, and he was pink and perfused, so there were no concerns with his circulation. Sam is bottle fed on demand. He was gaining weight and his mum reported he was feeding well 6-8 times a day. There were no concerns with his elimination as he passed urine and opened his bowels regularly. He had no history of pyrexia or hypothermia so it was not necessary to take his temperature. Sam lives at home with his mum and dad, the family appear happy and settled. Both parents seem to have bonded well with him. His mum is very good with him but is often keen to progress with Sam quicker than is advised by healthcare professionals. For example when Sam was having 3 hours off oxygen a day, his mum had disclosed she left him off for 5 hours, although this was against advice given. The nurse’s role is to reinforce the advice given without losing the good relationship with parents. Working in partnership with parents in the community after their children have been discharged involves handing control back to them, but this must be balanced with professional knowledge and expertise (Muller et al, 1992). Sam’s mother also had a tendency to compare his development with other babies of his age, forgetting to correct his age for his prematurity. The nurse reminded her that Sam was doing very well considering he was 3 months premature. As I was playing with Sam I found him to be very alert and receptive. He interacted well with me, smiling and giggling at stimulations. After conducting a thorough respiratory review and discussing Sam’s progress with his parents, the community nurse was able to advise them to advance him to 12 hours off oxygen a day. She informed Sam’s parents that another overnight sleep study would need to be conducted in the next few weeks, so the consultant would be able to confirm he was still coping well. Huband. S and Trigg. E (2000) Practices in Children’s Nursing; Guidelines for Hospital and Community. Harcourt Publishers Limited. McQuaid. L, Huband. S, and Parker. E (1996) Children’s Nursing. Churchill Livingstone. Singapore. Muller. D, Harris. P, Wattley. L and Taylor. J (1992) Nursing Children; Psychology, Research and Practice. Second Edition. Chapman and Hall. London. Roper. N, Logan. W and Tierney. N (1983) Using a Model for Nursing. Churchill Livingstone. Edinburgh.

Case for critical thinking: A flood of decisions Essay

1. What information sources (or potential information sources) could have been used to assist with the decision-making process for Wivenhoe Dam in this case? Potential information sources that could have been used to assist with the decision-making process for Wivenhoe Dam -SEQWater -Sought advice from Water Grid Manager -Water Commission -DERM (Department of Environmental Resource Management) Managerial decision-making Problem avoiders Problem solvers Problem seekers Approaches to decision making Classical decision model Behavioral decision model Judgmental decision model 2. With references to decision-making theory covered in the chapter, describe the type of managerial decision-making evident in this case, and the conditions under which decisions were made. Managerial Decision Making *Problem avoidably *Problem solvers *Problem seekers Decision conditions: *Certain environment *Risk environment *Uncertain environment 3. Evaluate the decisions made in the case in relation to the classical, behavioural and judgmental heuristics approaches to decision-making that are outlined in the chapter. Which model do you believe best describes the situation and subsequent decision-making process in this case? Justify your answer? Approaches to decision making ^Classical decision model ^Behavioral decision model ^Judgmental decision model Case decision *Classical decision model Problem: it was the flood that damage Brisbane and Ipswich Possible alternative: Not releasing flood waters. Consequently threatened stability of dam Optimizing decision: Release of flood waters being aware of potential damage. SWOT Analysis: Strengths: *New technology *They set priorities *Manage time Weakness: Lack of communication Misunderstanding Misconduct Problem solving Crisis Opportunities: *Professional engineer *Employment Threats: Natural disaster (climate change) Damage roads and homes. Conclusion People should make wise decision to save the lifes of the others.

The Crucible Parris Essay Example

The Crucible Parris Essay Example The Crucible Parris Paper The Crucible Parris Paper What clues does Arthur Miller give to the audience to suggest what will happen in the rest of the play? Millers comments in the overture set up The Crucible quite well. Certain descriptions and words give implicit meanings that do not come through until the end. There are also implicit meanings that do not require the reading of the play such as, A small window in the room. This gives a meaning of the things being small and the people being narrow-minded. Negative words in Millers opening comments such as small, exposed and raw describe the room as if it is very negative, more like a Puritan society. A Puritan society is when the Christian Church rules over the community and they live in strict morals and laws. The people are narrow-minded and live in a tyrannical state of authority. This suggests that the story may go on negatively as he describes it. Miller gives actions to Reverend Parris such as pressed turns on her and pointing at Betty are all angry, malicious and tense actions from a supposed religious man. These are not actions of a calm, wise man if the faith but one of a bag of nerves that may possibly be hiding something that may come apparent later as the storyline progresses. The audiences reaction to the first act of The Crucible would be one of shock, intrigue and a sense of it being enjoyable. The actions of Parris would shock the audience while also intriguing them, into what he will do later on, if he is still there. Also the actions of the Putnams and Abigail Williams would intrigue them but the child Abigail would give them some enjoyment. Miller presents Reverend Parris to the audience in this first act as a reasonably who is mentally unstable while being very protective about his family. This behaviour could lead the audience to believe that he will do this again later on. Parris language in this scene is sophisticated and short, to the point. This is shown in the stage directions as he is straight to the point and his words are getting shorter as well in his dialogue. Such instances are, No no, I cannot have anyone and Oh, pray not! Why, how does Ruth ail? The short sentences show that Parris is not giving anything away to the characters which shows Millers use of dramatic irony. We know that Parris has seen girls dancing in the woods which could show why he is slightly panicked. Parris language and tone of voice can suddenly change or give a new conviction to a person. When he is arguing with his niece, Abigail Williams, about the girls dancing in the woods and far from just accepting it as just sport he thinks they are conjuring spirits and practising witchcraft. (turns now, with new fear, and goes to Betty, looks down at her, and then gazing off): Oh, Abigail, what proper payment for my charity! Now I am undone. He is accusing Abigail for just taking him for granted. What he means by undone is his reputation. Miller suggests his reputation as a minister is more and more becoming dented by the accusation of witchcraft on his household. Abigail Williams is introduced to us as a, striking beautiful girl with the endless capacity for disassembling. This shows that Abby(Abigail) is a beautiful girl who can take things apart but this was not meant a literally. She can take peoples lives, families and reputations apart by using her beautiful looks or by some other means. The actions of Abby in the start of Act 1 as a timid servant to her uncle, Parris, but throughout the act she gains confidence and starts to accuse Tituba, the Negro slave, of raising the Devil but there is no proof of this. At the end of Act 1, however, we can see her endless capacity for disassembling when she wants to open herself to God and Betty mysteriously becomes awakened and accuses random people it seems, in the village. Abby joins Betty in this and accuses Goody Sibler of being with the Devil. The stage direction states, (It is rising with a great glee) and this direction shows Millers quickening of the accusations and the increased number of accusations. At the start of The Crucible Parris gives a sense of dramatic actions and one that could have lead to all the hysteria. Parris stage directions are, (scrambling to his feet in a fury. ) Miller shows him distraught and such an action to happen so quickly the audience would remember that clearly in the later scenes. The themes of causing hysteria are when Parris presses against Abby convicting her of conjuring spirits. (Pressed, turns on her), Parris is anxious to know what has happened to Betty and goes over the top with Abby, evading her personal space and with the play being performed would mean that it would look very effective.

Communication in Economics Essay Example | Topics and Well Written Essays - 500 words

Communication in Economics - Essay Example hased in by internet and there new governmental entities such as the City of Tucson City Council trying to impose similar sales imposition to raised their revenues. This paper provides an analysis of the pros and cons on the internet sales tax controversy. The government always wants to get their hands in any revenue generating scheme at any cost. The base by which critics refuse to recognize the right of a city such as Tucson to impose city tax sales is that most of the transactions are occurring outside their regional jurisdiction. If an online store is located in Toronto, Canada how does a government official justify that they have the right of collecting a sales tax from a Tucson citizen for purchasing good from that store. It is an outrageous claim by these city officials that such a transaction is legitimate. That is the as saying that a resident that goes to Canada on a tourism leisure trip should pay taxes to the cities on the purchase they make during their vacation. The timing and precise location of where the transaction took place is also an argument against the bureaucrats illogical idea. If the resident of Tucson goes outside the city borders with their laptop and makes a purchase in an online store in a different city t here is not way that Tucson would be eligible for a sales tax since the person was not in Tucson when the purchase was made. Their sales taxing system if approved would attempt and successful collect the tax due to the shipping address in Tucson which since the information taxing system does not differentiate between transactions since it is impossible to know where the actual took place when dealing with a virtual transaction. Governmental officials and lobbyist for taxing internet sales have a different perspective on the issue. To them not taxing internet sales is a discriminatory move against local merchants which are obligated to charge people sales tax, a move which raises the price of the items purchased. The merchants with

Response and Analysis Essay Example | Topics and Well Written Essays - 250 words - 1

Response and Analysis - Essay Example â€Å"Somewhere his family is weeping for him. His friends call for my blood. Maybe he had a girlfriend who really believed he would come back† (Collins 240). However, at the beginning of the game she thought that he is a enemy for her, that she will have to kill him to live. And after the claim that both of tributes can win the game, pace of the book suddenly speeded up. And the fight against the powerful tributes began. We can consider Catone as a negative character to be one of the tributes, despite the fact ,that he had the alliance with other experienced in killing tributes, he also didn’t have understanding of respect to the groupmates. He was cold-blooded killer and he left the Glimmer dying from the bites of insects. He didn’t want to help her, probably because she will fight with him when all other tribute will die. â€Å"Glimmer and another girl, the one from District 4, are not so lucky. They receive multiple stings before they’re even out of my view. Glimmer appears to go complete-190 ly mad, shrieking and trying to bat the wasps off with her bow, which is pointless. She calls to the others for help but, of course, no one returns.† Moreover, he was very sadistic and cruel for other tributes, even helpless and weak. He had no mercy towards the people who were less experienced. And after betrayal of Peeta, Cato has hate to everybody. â€Å"What are you still doing here?† he hisses at me. I stare uncomprehendingly as a trickle of water drips off a sting under his ear. His whole body starts sparkling as if he’s been dipped in dew. â€Å"Are you mad?† He’s prodding me with the shaft of the spear now. â€Å"Get up! Get up!† I rise, but he’s still pushing at me. What? What is going on? He shoves me away from him hard. â€Å"Run!† he screams.

Quantitative methodology Assignment Example | Topics and Well Written Essays - 4750 words

Quantitative methodology - Assignment Example Quantitative research methods try to measure variables by assigning scores to them in order to ensure that they can be scaled easily. The root of quantitative research lies in the positivist research paradigm that believes everything happens due to causal relationship between variables by virtue of some fixed law. It is useful to use quantitative research particularly when researchers are trying to test hypothesis. It is quite useful to use quantitative research under certain circumstances. For instance, according to Frankfort-Nachmias & Nachmias (1992 cited in Johnson, 2001) quantitative research is particularly important when the research problem is very specific and the researcher wants to measure the outcome numerically. The quantitative research is important because it helps the researcher to set the dependent and the independent variables of the research and is able to show the exact nature and direction of relationship between the variables. In short it allows the researcher to explain the causal relationship between the variables. Balsley (1970) had pointed out that quantitative research is particularly useful as the researcher is able to establish internal and external validity of the data due to controlled observations, experiments and proper data cleaning techniques. Additionally, quantitative research is also able to eliminate subjectivity and bias from the research by eliminating human bias factor. There are two main methods of quantitative research designs namely experiential and non-experiential research. Experiential quantitative research focuses on natural science based approach and non-experiential quantitative research focus primarily on social sciences (Johnson, Onwuegbuzie & Turner, 2007). There are basically four main types of quantitative research namely descriptive, correlational, casual-comparative and true experimental. Descriptive quantitative research

Time Value of Money Essay Example for Free

Time Value of Money Essay The application of the time value of money theory is very useful in the case of making a decision about obtaining a loan or rejecting it. According to the theory of time value of money, the rule of thumb for making down payment is: if your bank account pays lower rate than the loan, than use your money in the bank account as down payment. This rule is based on the realization of the fact that the value of the money which has been placed on the deposit is going to decline with time, and the percent rate on the deposit which the bank offers is not going to ensure that the value of the person’s money is kept on the same level. At the same time, the person could benefit from making a down payment for a car or any other object because the value of the money would reduce with time and thus he would be paying less for the object which he bought as the result of the loan. Despite the fact that the statements of the time value of money theory are obvious, the author of the article â€Å"Should You Pay Cash for a New Car?† in Los Angeles Times seems to regard all of the issues connected with consumer loans in a different light. Most of the points which he makes in the article are either completely incorrect or need to be altered in order to correspond with the statements which theory of time value of money makes. First of all, the author marks that it is always much better for consumers to obtain loans at the bank instead of investing their own money which they have in deposits. He mentions that consumers did not have computers in order to calculate the benefits of obtaining loans. If they had, â€Å"they might otherwise have seen the advantage in borrowing without taking anyones word for it†. However, as the rule of thumb states, it is profitable to make a down payment for the loan only in that case when the bank account pays a lower rate than the loan. The author does not take this rule into consideration and makes a statement that all of the consumers need to obtain loans, despite the differences between the rates of interest on deposits and loans. The point of view which he is trying to express is that no matter what, obtaining a loan will always be the best possible solution for the consumer. The author mentions the rule which Frank Sperling, vice president at Security Pacific National Bank gives in order to guide consumers in making a choice for or against consumer loans: if a consumer is able to obtain at least half of the interest rate on the investment in comparison with the interest rate on the loan, he is going to make a correct choice by obtaining a loan. This rule is quite similar to the rule of thumb which is being used in the theory of time value of money but it is too concrete of a case. It is impossible to make a conclusion about the interest rate on investment being exactly half of the interest rate on the loan for the deal to be beneficial for the consumer. The benefits of the consumer can be relatively larger if the gap is increased but the consumer can make a down payment for the item which he wants to buy whenever the rate on the loan excesses the yield on investment. The author also states that there can be differences between the rule applications for different types of loans but it is not true because the rule can be applied for any type of loan. It is based on the general objective principles on the theory of time value of money which are universal. Besides, the approach which the author describes does not work in any economic environment. The consumer needs first to realize in what environment the country’s economy is functioning at this point. This can be either the environment of increasing interest rates or of decreasing interest rates. If the interest rates are going to decline in the future, the consumer will need to consider an option of refinancing the loan in the future. If the interest rates are increasing, the consumer might think of obtaining a loan with a lower interest rate now and investing his funds in securities which a higher interest rate in the following periods of time. He also needs to consider the possibilities of obtaining a fixed interest rate for the loan in order to ensure that his payments on the loan are not increasing and invest in floating-rate securities in order to benefit from the interest rate fluctuation in the future. Without the analysis of the economic environment, there is no possibility to make a conclusion about the best possible way of buying a car or any other item. The author also makes an incorrect statement that the major difference between making an investment and obtaining a loan is that the percent rate is calculated on a different basis. According to him, the percent rate on the loan is being compounded only annually and the rate of interest on the investment can be compounded monthly: â€Å"Keppel†¦ calculated that 48 months of interest on a 14.2 percent loan of $8,239.05 would be $2,607.62, while the same principal invested at 8 percent, compounded monthly would earn interest of $3,095.06- a profit of $487.44†. However, this rule is going to be true only in the case when both the loan and the investment have the mentioned characteristics. It is not the general case because interest rates on loans as well as on any other assets can be compounded in any number of ways. It is impossible to say that the investment is going to bring profits to Keppel only due to the different techniques of interest calculations because it is very far from the truth. The question is whether he will be able to obtain the loan and make the investment according to the terms which are favorable for him. The author of the article has expressed complete ignorance in the knowledge of the finance and particularly their theory of time value of money. In order to make a correct decision about the way of purchasing an item, consumers need to make sure they take all of the issues of this theory into consideration.

Exosome as Nanoscale Vesicles | Pancreatic Cancer Research

Exosome as Nanoscale Vesicles | Pancreatic Cancer Research Abstract Exosome are nanoscale vesicles that are released from cancer cells, playing an important role in the microenvironment of cancerous tumour cells.6,8 The exosomal vesicles (EV) contribute to the progression and growth of the tumour, and can be targeted using gold nanoparticles (GNP).1,6,7 The exosomes are isolated from the blood plasma, and with their stability in bodily fluids, they can be targeted and inhibited using GNP.   The GNP will inhibit the cancer cell, and will stop tumour growth and production.   Using proteomic and quantitative methods, the exosome EphA2, showed the highest detection of specificity and sensitivity in pancreatic cancer patients.1,2,4,8 Further tests confirmed that EphA2-EV has potential in early detection for pancreatic cancer, due to the levels specificity and sensitivity being higher in comparison to pancreatitis patients and the control patients.1 Keywords: Biomarkers, Exosome, Pancreatic cancer, Nanoparticle, Proteomics, Vesicles, Plasma, Antibody Introduction Pancreatic cancer, is vastly terminal, with a survival rate of less than 5%.   Pancreatic ductal adenocarcinoma (PDAC), is the most common form of exocrine pancreatic cancer, accounting for around 95% of pancreatic cancer cases.10 PDAC is a silent cancer, and with the lack of testing, the need for novel biomarkers to aid in early detection is imperative.   With no valid early detection methods, and no symptoms of early stage PDAC, the cancer will progress rapidly throughout the body before it is detected.   There is need to find a biomarker, aiding in the early detection PDAC, so that a treatment can be provided to stop the cancer from progressing.   The current tumour biomarker, CA19-9, is not reliable in early detection due to falsely elevated results of diseases other than PDAC.10 Recent studies suggest that exosomes, a nanovesicle, has a high potential as the future biomarker of PDAC, due to the stability and detection sensitivity in human blood plasma.1,2,4,8 Malicious exosomes, are veiled by cancer cells, screening the importance in tumour maturation and progression.7 Studies show how to optimize a method, to isolate exosomes from the blood plasma, to further assist in biomarker discovery.   In regards to analysing exosomes as a potential biomarker, exosomes need to purified and isolated with differential centrifugation paired with ultracentrifugation (UC).   Another technique used, is affinity purification of the exosomal membrane antigens using density gradient (DG) centrifugation, separating the vesicles based on their density.8 A practise needs to be conducted, to purify exosomes, from only a small volume of blood plasma. With studies being conducted on the stability in fluids of circulating exosomes, it can be confirmed that these nanovesicles have the ability of targeting to uptake to hinder or delay tumour development.   With the size of the exosomes ranging from 40 100 nm, they are distinguished for tumour microenvironment.   Exosomes, a potential biomarker, for the early detection of PDAC, are also being studied as potential nanocarriers to target cancer cells and delaying tumour growth.1,7,8 The most common nanocarrier being studied is the gold nanoparticle (GNP), due to its imaging, diagnostics, and therapy abilities.   The GNP can be easily synthesized via the citrate reduction, which is why is has potential in medical theranostics.7 Extracellular vesicles (EV), are secreted into extracellular space, they are involved in tumour initiation, progression as well as metastasis.   EVs can be used as non-invasive biomarkers, but the current studied methods are time consuming in regards to EV isolation.1,7,8 The EV membrane markers which are part of the tetraspanin family, are CD9, CD63, and CD81, respectively, and an assay demonstrates similar features.6 A nanoparticle EV assay, will be captured by an EV-specific antibody with the dual binding of EV, using 2 nanoparticle probes.   The 2 nanoparticle probes, will produce a plasmon, promoting an increase in sensitivity and specificity for the discovery of an exosomal biomarker.   Ephrin type A receptor 2 (EphA2), has recently been identified as a biomarker, of the tumour derived pancreatic cell line, and enriched on EV.1   EphA2, shows overexpression, increases in vitro invasiveness and anoikis resistance in pancreatic cancer cell lines.1 A recent study has been conducted with healthy control patients, pancreatitis patients as well as pancreatic cancer patients, with the use of nanoplasmon-enhanced scattering (nPES) assay a fast, sensitive, and specific method in biomarker detection. Convention Tumour Markers in Pancreatic Cancer Carcinoembryonic Antigen CEA CEA, is a glycoprotein, that is measured in a common blood test used for testing patients with cancer, including pancreatic cancer.   This will measure the amount of the CEA protein that is in the blood of a patient who may have cancer, and the CEA levels can be used to determine whether treatment is working or if the cancer is spreading.   A CEA level of 5 ng/mL, is considered a normal level of this protein, but there are several conditions that can alter the levels of the CEA in your blood, which is why this is not a valid biomarker in the detection of pancreatic cancer.5 CEA testing can be useful in regards to recurrent colon cancer as well seeing if treatment is successful.   Levels of CEA can be elevated due to smoking, as well as in other diseases such as Crohns disease.   Due to the unreliability of CEA levels in cancer, this blood test confirms that CEA is not a consistent biomarker for the early detection of pancreatic cancer. CEA is expected to be paired with other biomarkers, for early detection reasons.   When paired with CA19-9, there is an increase in detection for sensitivity and specificity, showing an improvement in diseases including pancreatitis as well as pancreatic pseudocyst.   Despite the improved results for pancreatic diseases, CEA is still not valid for the detection of pancreatic cancer, even when it is paired with another marker such as CA19-9.5 Carbohydrate Antigen CA19-9 Carbohydrate antigen (CA19-9) was discovered in 1981, and is considered a sialyl lewis a (sLea).9 CA19-9 is found on the surface cancer cell, expressed as a glycolipid and an O linked glycoprotein, and is related to the Lewis blood group antigens.3   Patients with Le (alpha beta +) or Le (alpha + beta -) blood group, express levels of CA19-9 in their blood, whereas approximately 5 10% of patients with Le (alpha beta -) blood group do not express CA19-9, limiting the use as a valid biomarker.9 Due to the low, and uncertain sensitivity of CA19-9, it is a poor interpreter of PDAC, therefore it is not a valued biomarker. CA19-9 is unable to differentiate between benign, precursor lesions and malignant conditions in PDAC patients, and it gives elevated results in many other gastrointestinal cancers.3   This blood test can show elevated CA19-9 levels in patients with other non-cancer diseases including pancreatitis and cirrhosis.3,9 The CA19-9 blood test can be beneficial in regards to knowing if a pancreatic tumour is secreting it, and to judge the efficiency of treatment, and look for pancreatic cancer recurrence.   A healthy patient will have a CA19-9 level of 0 37 U/mL, therefore with increasing levels of CA19-9, this could indicate tumour growth.3 For more accurate results, a PDAC marker needs to be discovered and paired with CA19-9, to increase the sensitivity and specificity in early detection.   With CA19-9 as the only marker, studies show it was only elevated in 50 75% of patients having PDAC, confirming that is not consistent as a biomarker and should not be used in diagnostic testing.3,9 Expressing elevated levels in other diseases such as benign jaundice, pancreatitis, and ovarian cancer, confirms the lack of consistency using the CA19-9 marker and that it cannot be used as an accurate indication of early pancreatic cancer detection.3 Emerging Biomarkers With the absence of reliability using the current PDAC biomarker, C19-9, it is a necessity to discover a biomarker with improved sensitivity as well specificity for the early detection of PDAC.   Recent studies suggest, that exosomes can be detected in body fluid such as blood, and they have potential as disease biomarkers.   Exosomes, found in blood plasma, need to be collected from healthy patients to obtain individual and pooled samples.   The collected blood plasma, will need to be separated, by centrifugation, to isolate the exosomes for further proteomic and quantitative studies.8 Isolation Methods Isolation of exosomes using the UC method, involves normal human plasma, and diluting it with PBS.   The sample will be differentially centrifuged, to eradicate cell debris, which is followed by UC.   The subsequent pellet, is washed in PBS, and filtered, and the filtrate was ultracentrifuged.   The resulting exosomal pellet, used for the study, will be resuspended in PBS.8 Using the EI isolation method, the plasma, is diluted in PBS and centrifuged.   The supernant is filtered, and the filtrate will be incubated using a blocking agent.   A microcolumn was placed in magnetic separators, where the column was rinsed with rinsing solution.   Beads were bound to the exosome, and were applied to the magnetic column.   The column will be washed with rinsing solution, and the immune captured exosomes were recovered by removing them from the column and placing them in a collection tube.   The exosome bound microbeads are washed to elute the exosomes, and centrifuged to obtain the exosomal pellet.   The exosomal pellet will be resuspended in PBS.8 Lastly, isolation using DG method, involved the exosomal pellet that was obtained from UC as well as normal blood plasma that was layered on iodixanol solution and centrifuged.   To the top of the tube, there were 12 fractions, with increasing densities.   The fractions are diluted with PBS and centrifuged, the resulting pellet was washed with PBS, centrifuged and resuspended in PBS.8 Western Blot and Microscopic Analyses The western blot method, shows the enrichment of the exosomal marker proteins.   Gel electrophoresis is used to separate and identify the different proteins.   The thickness of the band, indicates the amount of the protein that is present.   There is a labelled antibody, that is bound to the protein of interest.   AFM is used, to get a 3D image of the exosomal vesicle. Recent studies confirma that the exosomal markers CD9 and CD63 are enriched in exosomes purified using UC and EI methods.8 The study indicates that the UC method, had four exosomal markers whereas the EI method had only two exosomal markers, CD9 and CD63.   Transmission electron microscopy (TEM) and atomic force microscopy (AFM), were used on the isolated exomes, from the three exosomal isolation techniques.   In the DG sample, the TEM reported homogeneous vesicle, with diameter ranging from 40 100 nm, confirming the characteristics of exosomes.   The AFM produced a 3D image of the exosome, and after further analysis it was revealed that the exosomes had round membranous vesicle characteristics. LC-MS/MS Liquid chromatography mass spectrometry (LC-MS/MS), is a quantitative method used for the identification of proteins at the peptide level.   The first quadrupole is for the selection of the precursor and the second quadrupole is highly specific for detection.   In comparison to gas chromatography mass spectrometry (GC-MS), LC-MS/MS is not limited to volatile substances, it is better for the detection of molecules.   LC-MS/MS can produce many quantitative results, and has a high specificity and sensitivity. The study was carried out, using an LTQ Orbitrap Velos with a nanoelectrospray interface coupled to an Ultimate 3000 RSLC nanosystem and the LTQ Orbitrap Velos mass spectrometer operates using a nano -ESI spray.   The LC-MS/MS spectra are searched against the human protein database using MASCOT.   Equal amounts of protein from the three exosomal samples were separated, reduced, alkylated and digested with trypsin.   The DG sample had the highest number of protein identifications, followed by the UC isolation method.   Therefore, the western blotting, microscopy and MS results confirm that the DG isolation method is the most effective, in regards to isolating exosomes from blood plasma.8 Targeting with Gold Nanoparticles Malicious Exosomes The exosomes are formed from endosomal pathways, after they are fused from multivesicular bodies (MVBs) with plasma membrane.   The formation of malicious exosomes, also starts in the endosomal pathway.   The early exosome is formed from the migration from the cell periphery to the nucleus, by the formation of intraluminal vesicles (ILV).   The process interceded by exosomal complexes required for transport (ESCRT) and other proteins.   Late exosomes/ MVB, migrate to the periphery and fuse with the membrane, releasing the ILV, which are called exosomes.   The proteins, Rab GTPases, mediate the endosome migration.7 The malicious exosomes, are released from cancer cells found in the tumour microenvironment.   Exosomes play a role in variation and shaping of that tumour microenvironment.1,2,4,6,8 Malicious exosomes have potential as biomarkers, due to their stability in biological fluids including blood plasma.   There have been increased levels of circulating exosomes seen in several cancers including pancreatic cancer.1,6,7,8 Nanovesicles can be used to carry therapeutics, and have potential to limit cancer progression.1,7 The method consists of inhibiting the malicious exosomes biogenesis. Gold Nanoparticles The GNPs can be easily synthesised, as well they consist of a variety of shapes and sizes.   These nanoparticles exhibit intense light absorption and scattering, and they are deemed to be highly stable.1,7   They have potential in targeting, therapeutics as well as diagnostic capabilities. Regarding rapid tumour growth, a compressed lymphatic vessel will collapse causing lymph drainage, which will then allow for the nanosized molecule to be taken at the tumour site.7 This process will allow for passive targeting with nanosized molecules.   The cellular interest will be dependent upon the size and shape of the GNP.1,7 The tumour cells will overexpress their cell number receptors, which can be used for potential biomarkers.1,2,4,6,7,8 These cell surface receptors, will aid in the direction of the GNP to the tumour cells. Gold Nanoparticle Targeting The GNP will target malicious exosomes, by undertaking the malicious exosomes biogenesis with GNP specific targeting moieties as well as silencing moieties.7   Using antibodies to aim at the exosome for capture and selective retention.   Lateral flow immunoassay, will aid in exosome detection with CD9 and CD81 as antibodies, and CD63 with GNP.1,7 Therefore, GNP are being studied as a potential candidate for cancer therapy as well as for malicious exosome targeting.   The use of nanotheranostics to help quantify and inhibit the malicious exosomes. Sample Collection and Processing This recent study, developed a method for the purification of exosomes in blood plasma, as well as finding the EV concentrations in the plasma samples.   A three-probe EV capture was used, with a capture antibody that recognizes an EV membrane protein (anti-CD81), with antibody conjugated AuS and AuR to serve as two EV probes.   This EV capture was designed to form a plasmon, with the different GNP binding on an EV to improve sensitivity and specificity of EV detection.1   The study examined 59 pancreatic cancer patients, 48 pancreatitis patients, and 48 control patients, to see if early pancreatic cancer stage could be distinguished from pancreatitis patients and the control patients.1 Method The EV isolation consisted of cells grown in culture media, and washed with PBS.   The culture supernatants were collected and centrifuged to pellet cells, and centrifuged again to remove cell debris.   Concentrated with centrifugal filtering units, and centrifuged, the precipitates were collected and resuspended in PBS and centrifuged.   The resulting precipitates were collected and dissolved in PBS.   The ELISA assay, consisted of ninety-six well plates, which were incubated with antibody CD81.   The ELISA assay was analysed for absorbance, and the standard curve plotted the light absorbance versus the log10 EV standard concentration in pg/uL.1 The peptides were separated using Ultimate 3000 nano-LC, with an enrichment column as well as an analytical column.   The peptide fractions were analysed with Velos Dual-Pressure Linear Ion Trap mass spectrometer, and one MS scan, was followed by eight MS/MS scans. The nPES platform was constructed by filling sample wells with plasma sample or cell culture EV samples, followed by incubation and being washed three times with PBST and three times with PBS.   The sample wells were then filled with AuS and AuR PBST solution, and were incubated and washed three times each with PBST and PBS, respectively.   The sample wells were fitted with a cover slip and dark-field microscopy (DFM) was used for imaging.   The DFM images, that had image areas with brightness equal to 225 were selected, and the ratio of the image area to the whole image gave area ratios that were indicative to the nPES EV signal.1 A standard concentration curve was generated with a linear regression of nPES area ratio with log10 concentrations.1 SEM images analysed the images of GNP binding to EV, from EVs that were purified from human plasma.   The purified EVs were hybridized with anti-CD63-AuS and anti-CD9-AuR.   The SEM fields were analysed to calculate the total EVs, as well as the number of GNP-bound EVs per um2 of each assay. Proteomics and the Early Detection of PC An nPES was previously designed, for EV detection using GNP, that can scatter light at different wavelengths indicative to their shape and size.   Using both gold nanospheres (AuS) as well as gold nanorods (AuR), a plasmon is formed, increasing the scattering intensity.   With the plasmon, antibodies against CD9, CD81, and CD63 can capture and detect EV in a sample.1,7   AuS and AuR are detectable using dark field microscopy (DFM), and will form the complexes AuS-EV-AuR, AuS-EV and AuR-EV.   These complexes can be analysed using scanning electronic microscopy (SEM), examining the binding and distribution.   Following the pure preparation of EV samples, EV plasma was added to give the EV plasma standard.   The anti CD81 was incubated with the standard and two antibodies conjugated GNPs, AuS-Anti-CD63 and AuR-Anti-CD9, which exhibited ratios >0.35%.   A comparison was done with nPES and enzyme linked immunosorbent assay (ELISA), of the sensitivity and linearity of thei r EV values.   The nPES assays showed to be highly sensitive, requiring less plasma as well has exhibiting more advantages over ELISA in regards to measuring EV concentrations.1 Since CA19-9 is the only accepted pancreatic cancer marker that is not valid, pancreatic cancer derived EV marker is a more feasible biomarker due to the multiple factors that the pancreatic cancer cells express.   The nPES assay will quantitate tumour derived EV from blood samples, and one of the two EV specific GNP were replaced with one specific for the membrane protein.   LC-MS/MS proteomics, bioinformatics is used to identify trans-membrane proteins on EV PC (PANC-1 and MIAPaCa-2) and PDAC (BxPC-3).1 There were 128 membrane proteins identified, and 26 were expressed on EV.   The EphA2 showed the highest expression and is associated with cancer progression, metastasis, and prognosis.   The EphA2, was also not expressed by EV in HPNE. EphA2 was chosen as the potential marker, and CD81 and CD9 were chosen for EV capture.   The nPES was modified, using one capture antibody (anti-CD81) and two antibody-conjugated GNP probes (anti-EphA2-AuS and anti-CD9-AuR).1 The plasma EphA2-EV levels were higher in pancreatic cancer patients, in comparison to pancreatitis patients and the normal control (NC).   With the strong association between the circulating EphA2-EV and early stage pancreatic cancer, there is potential for EphA2-EV to be used as an early detection marker.1   The CA19-9 levels were increased in the pancreatic cancer patients in comparison to the pancreatitis patients and the NC, but the levels were not increased in the early stages of PC.   The receiver operating characteristic (ROC) curves, showed that the plasma EphA2-EV levels are promising in the classification of pancreatic cancer stages. The current EV analysis methods are tedious and lengthy for the isolation procedures, as will having volume requirements.   The nPES platform that has been studied, assimilates EV capture and detection with the use of the plasmon coupling effect, to have an increase in both detection sensitivity and specificity in small volume samples and fast sensitive biomarker quantification.   This EV nPES platform, can be generalizable for any disease state that has a specific EV marker.1  Ã‚   The nPES EphA2-EV blood assay shows substantial value regarding pancreatic cancer screening tests, due to being a rapid, accurate and non-invasive blood test for the early diagnosis of pancreatic cancer. Conclusions This review article explains the need to find a valid biomarker in the early detection of pancreatic cancer, as well as discussing how exosomes have potential to be that marker in the early detection process.1,2,4,6,7,8   The existing biomarkers for pancreatic cancer, are not valid markers in the early detection due to the lack of sensitivity and specificity that they exhibit when differentiating between benign and malignant stages.   The use of exosomes for the early detection of pancreatic cancer, shows potential as a biomarker, with the use of nPES platform.1 The platform allows for EV capture using plasmon coupling, which increases in detection sensitivity and specificity, which allows for the discovery of an ultrasensitive biomarker.   The nPES EphA2-EV assay could differentiate between pancreatic cancer patients (stage I and II) and pancreatitis and NC patients.1 The role of EphA2-EV, could help to improve early detection rates as well as improving patient outcome, and th is blood test is inexpensive, accurate and non-invasive.   This review involved proteomic and quantitative methods, to find a novel biomarker for the early detection of pancreatic cancer, and non-invasive nPES EphA2-EV analysis can aid in improving early pancreatic cancer detection and treatment. 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This theme is an influence from Poes life and the relevant Gold Rush of 1849 (Coad 60). The literary devices, symbols, relevancy, and personal experiences offer a deeper meaning to the poem than what lies on the surface. Poes skillful use of these elements helps to stress the ignorant desire humans have for wealth and fortune. The poem delivers a reflective moral issue many readers can, in some way or another, relate to. Poe uses the word shadow in each of the four stanzas of the poem, each stanza consisting of six lines. The third line in each stanza is where the use of the word shadow is introduced. Though the word occurs multiple times, it has a different meaning each time. The first shadow represents a literal shadow, a casting shadow of the sun. It could also be interpreted as happiness and sadness. The second shadow represents the shadow that has overcome the knights heart after much unsuccessful searching. The third shadow represents a live figure, possibly his or maybe an angel. And the fourth shadow figuratively refers to Valley of the Shadow (21). The fact the knight has grown old and weak, and must cross Over the Mountains Of the Moon, Down the Valley of the Shadow is seen as a symbol of the knights death, relating to the Biblical valley of death (19-21). Through Poes use of the word shadow and the period in which the poem was written, readers can understand Poes message. Poe uses the shadow in each stanza to convey his message. As the meaning of the shadow changes, so do readers emotional state. As he begins the first stanza, readers see a happy, gaily, bedighted knight who is enthusiastic about going on his search for gold. This start gives readers a sense of happiness and jolt of energy. His shadow could also be a foreshadowing of future events. However, Poe begins the second stanza with the word But. This contradictory word signals a shift between the first and second stanza and also a shift in emotion. The knight has become old, disheartened, and dismayed as the shadow is used in context to signal the emotional state of the knight. This signal causes readers to suddenly have a change in emotion; readers become sympathetic towards the knight. Poe continues to elaborate on the disappointment of the knight in stanza three. The knight encounters a live or possibly imaginative figure and asks the shadow where is Eldorado, reflecting on his hopeless jo urney in which he wasted his life. This figure could possibly be an angel providing guidance, an angel of death, or even himself. As the shadow replies to the question in stanza 4, readers are left with the idea that he has come to the end of his life and has died. With the closing of the poem, the audience can relate to the pain the knight feels. In all, the repetitive shadow becomes engraved in the readers mind, helping to sway the emotions. The life of the knight also provides a moral for people to learn. Poes moral in Eldorado is not to seek for riches on earth. The only true riches are the riches one receives after death. The knight in the poem seeks for physical riches for many years without any hope, leaving him disheartened and at the end of his life. When asked where Eldorado could be, the knight was told Down the Valley of the Shadow (21). This insinuation emphasizes the main point that true riches are found in Heaven, not earth, and any riches sought on earth leads to despair and death. As suggested by The Meaning of Poes Eldorado by the John Hopkins University Press, it can be argued Poe portrayed himself as the knight (Coad 60). Poe published his poem in 1849, the same year as his death. Like the knight, Poe had sought after an accomplished life, which he failed to do during his life. He was also unstable in the last years of his life. However, the knight most probably was a reference to the many prospectors of the California Gold Rush, which took place during the time the poem was written. The poem may have been Poes warning to the many prospectors that would experience the same hardships of the knight. Poes repetition of shadow and Eldorado and use of other symbols play an important part in his poem. It helps to further stress his main point. Other such devices Poe uses to communicate to his audience is through auditory and imagery senses. Poe uses aabccb rhyme scheme in the first three stanzas and xxabba rhyme scheme in the fourth stanza of his poem . Poes creatively written stressed and unstressed poem is one way Poe remarkably appeals to the readers auditory and imagery senses. The use of this rhyme scheme creates a thumpity, thump sound when read aloud, bringing the clattering of the horses trot to life. The symbols and rhyme scheme helps to immerse the reader into the scene of the poem and drives them to continue reading until the end. Eldorado is a poem by Edgar Allan Poe that has a stressed message to readers. It tells the story of a knight who traveled for a period of his life searching for a city of gold, Eldorado. It provides a message to all readers that true riches and happiness are only acquired through Heaven after death. If one attempts to search for wealth, in hopes happiness will follow, that person will come to the end of their life saddened and in despair. Poes use of symbols, rhyme scheme, and repetition brings life to his poem, which keeps the readers entertained and helps to convey his message. The poem brings light to the life of everyone and anyone searching for happiness and wealth on earth. Thus, Eldorado is Over the Mountains Of the Moon, Down the Valley of the Shadow, Ride, boldly ride . . . If you seek for Eldorado! (19-24).