Quantitative methodology Assignment Example | Topics and Well Written Essays - 4750 words

Quantitative methodology - Assignment Example Quantitative research methods try to measure variables by assigning scores to them in order to ensure that they can be scaled easily. The root of quantitative research lies in the positivist research paradigm that believes everything happens due to causal relationship between variables by virtue of some fixed law. It is useful to use quantitative research particularly when researchers are trying to test hypothesis. It is quite useful to use quantitative research under certain circumstances. For instance, according to Frankfort-Nachmias & Nachmias (1992 cited in Johnson, 2001) quantitative research is particularly important when the research problem is very specific and the researcher wants to measure the outcome numerically. The quantitative research is important because it helps the researcher to set the dependent and the independent variables of the research and is able to show the exact nature and direction of relationship between the variables. In short it allows the researcher to explain the causal relationship between the variables. Balsley (1970) had pointed out that quantitative research is particularly useful as the researcher is able to establish internal and external validity of the data due to controlled observations, experiments and proper data cleaning techniques. Additionally, quantitative research is also able to eliminate subjectivity and bias from the research by eliminating human bias factor. There are two main methods of quantitative research designs namely experiential and non-experiential research. Experiential quantitative research focuses on natural science based approach and non-experiential quantitative research focus primarily on social sciences (Johnson, Onwuegbuzie & Turner, 2007). There are basically four main types of quantitative research namely descriptive, correlational, casual-comparative and true experimental. Descriptive quantitative research

Time Value of Money Essay Example for Free

Time Value of Money Essay The application of the time value of money theory is very useful in the case of making a decision about obtaining a loan or rejecting it. According to the theory of time value of money, the rule of thumb for making down payment is: if your bank account pays lower rate than the loan, than use your money in the bank account as down payment. This rule is based on the realization of the fact that the value of the money which has been placed on the deposit is going to decline with time, and the percent rate on the deposit which the bank offers is not going to ensure that the value of the person’s money is kept on the same level. At the same time, the person could benefit from making a down payment for a car or any other object because the value of the money would reduce with time and thus he would be paying less for the object which he bought as the result of the loan. Despite the fact that the statements of the time value of money theory are obvious, the author of the article â€Å"Should You Pay Cash for a New Car?† in Los Angeles Times seems to regard all of the issues connected with consumer loans in a different light. Most of the points which he makes in the article are either completely incorrect or need to be altered in order to correspond with the statements which theory of time value of money makes. First of all, the author marks that it is always much better for consumers to obtain loans at the bank instead of investing their own money which they have in deposits. He mentions that consumers did not have computers in order to calculate the benefits of obtaining loans. If they had, â€Å"they might otherwise have seen the advantage in borrowing without taking anyones word for it†. However, as the rule of thumb states, it is profitable to make a down payment for the loan only in that case when the bank account pays a lower rate than the loan. The author does not take this rule into consideration and makes a statement that all of the consumers need to obtain loans, despite the differences between the rates of interest on deposits and loans. The point of view which he is trying to express is that no matter what, obtaining a loan will always be the best possible solution for the consumer. The author mentions the rule which Frank Sperling, vice president at Security Pacific National Bank gives in order to guide consumers in making a choice for or against consumer loans: if a consumer is able to obtain at least half of the interest rate on the investment in comparison with the interest rate on the loan, he is going to make a correct choice by obtaining a loan. This rule is quite similar to the rule of thumb which is being used in the theory of time value of money but it is too concrete of a case. It is impossible to make a conclusion about the interest rate on investment being exactly half of the interest rate on the loan for the deal to be beneficial for the consumer. The benefits of the consumer can be relatively larger if the gap is increased but the consumer can make a down payment for the item which he wants to buy whenever the rate on the loan excesses the yield on investment. The author also states that there can be differences between the rule applications for different types of loans but it is not true because the rule can be applied for any type of loan. It is based on the general objective principles on the theory of time value of money which are universal. Besides, the approach which the author describes does not work in any economic environment. The consumer needs first to realize in what environment the country’s economy is functioning at this point. This can be either the environment of increasing interest rates or of decreasing interest rates. If the interest rates are going to decline in the future, the consumer will need to consider an option of refinancing the loan in the future. If the interest rates are increasing, the consumer might think of obtaining a loan with a lower interest rate now and investing his funds in securities which a higher interest rate in the following periods of time. He also needs to consider the possibilities of obtaining a fixed interest rate for the loan in order to ensure that his payments on the loan are not increasing and invest in floating-rate securities in order to benefit from the interest rate fluctuation in the future. Without the analysis of the economic environment, there is no possibility to make a conclusion about the best possible way of buying a car or any other item. The author also makes an incorrect statement that the major difference between making an investment and obtaining a loan is that the percent rate is calculated on a different basis. According to him, the percent rate on the loan is being compounded only annually and the rate of interest on the investment can be compounded monthly: â€Å"Keppel†¦ calculated that 48 months of interest on a 14.2 percent loan of $8,239.05 would be $2,607.62, while the same principal invested at 8 percent, compounded monthly would earn interest of $3,095.06- a profit of $487.44†. However, this rule is going to be true only in the case when both the loan and the investment have the mentioned characteristics. It is not the general case because interest rates on loans as well as on any other assets can be compounded in any number of ways. It is impossible to say that the investment is going to bring profits to Keppel only due to the different techniques of interest calculations because it is very far from the truth. The question is whether he will be able to obtain the loan and make the investment according to the terms which are favorable for him. The author of the article has expressed complete ignorance in the knowledge of the finance and particularly their theory of time value of money. In order to make a correct decision about the way of purchasing an item, consumers need to make sure they take all of the issues of this theory into consideration.

Exosome as Nanoscale Vesicles | Pancreatic Cancer Research

Exosome as Nanoscale Vesicles | Pancreatic Cancer Research Abstract Exosome are nanoscale vesicles that are released from cancer cells, playing an important role in the microenvironment of cancerous tumour cells.6,8 The exosomal vesicles (EV) contribute to the progression and growth of the tumour, and can be targeted using gold nanoparticles (GNP).1,6,7 The exosomes are isolated from the blood plasma, and with their stability in bodily fluids, they can be targeted and inhibited using GNP.   The GNP will inhibit the cancer cell, and will stop tumour growth and production.   Using proteomic and quantitative methods, the exosome EphA2, showed the highest detection of specificity and sensitivity in pancreatic cancer patients.1,2,4,8 Further tests confirmed that EphA2-EV has potential in early detection for pancreatic cancer, due to the levels specificity and sensitivity being higher in comparison to pancreatitis patients and the control patients.1 Keywords: Biomarkers, Exosome, Pancreatic cancer, Nanoparticle, Proteomics, Vesicles, Plasma, Antibody Introduction Pancreatic cancer, is vastly terminal, with a survival rate of less than 5%.   Pancreatic ductal adenocarcinoma (PDAC), is the most common form of exocrine pancreatic cancer, accounting for around 95% of pancreatic cancer cases.10 PDAC is a silent cancer, and with the lack of testing, the need for novel biomarkers to aid in early detection is imperative.   With no valid early detection methods, and no symptoms of early stage PDAC, the cancer will progress rapidly throughout the body before it is detected.   There is need to find a biomarker, aiding in the early detection PDAC, so that a treatment can be provided to stop the cancer from progressing.   The current tumour biomarker, CA19-9, is not reliable in early detection due to falsely elevated results of diseases other than PDAC.10 Recent studies suggest that exosomes, a nanovesicle, has a high potential as the future biomarker of PDAC, due to the stability and detection sensitivity in human blood plasma.1,2,4,8 Malicious exosomes, are veiled by cancer cells, screening the importance in tumour maturation and progression.7 Studies show how to optimize a method, to isolate exosomes from the blood plasma, to further assist in biomarker discovery.   In regards to analysing exosomes as a potential biomarker, exosomes need to purified and isolated with differential centrifugation paired with ultracentrifugation (UC).   Another technique used, is affinity purification of the exosomal membrane antigens using density gradient (DG) centrifugation, separating the vesicles based on their density.8 A practise needs to be conducted, to purify exosomes, from only a small volume of blood plasma. With studies being conducted on the stability in fluids of circulating exosomes, it can be confirmed that these nanovesicles have the ability of targeting to uptake to hinder or delay tumour development.   With the size of the exosomes ranging from 40 100 nm, they are distinguished for tumour microenvironment.   Exosomes, a potential biomarker, for the early detection of PDAC, are also being studied as potential nanocarriers to target cancer cells and delaying tumour growth.1,7,8 The most common nanocarrier being studied is the gold nanoparticle (GNP), due to its imaging, diagnostics, and therapy abilities.   The GNP can be easily synthesized via the citrate reduction, which is why is has potential in medical theranostics.7 Extracellular vesicles (EV), are secreted into extracellular space, they are involved in tumour initiation, progression as well as metastasis.   EVs can be used as non-invasive biomarkers, but the current studied methods are time consuming in regards to EV isolation.1,7,8 The EV membrane markers which are part of the tetraspanin family, are CD9, CD63, and CD81, respectively, and an assay demonstrates similar features.6 A nanoparticle EV assay, will be captured by an EV-specific antibody with the dual binding of EV, using 2 nanoparticle probes.   The 2 nanoparticle probes, will produce a plasmon, promoting an increase in sensitivity and specificity for the discovery of an exosomal biomarker.   Ephrin type A receptor 2 (EphA2), has recently been identified as a biomarker, of the tumour derived pancreatic cell line, and enriched on EV.1   EphA2, shows overexpression, increases in vitro invasiveness and anoikis resistance in pancreatic cancer cell lines.1 A recent study has been conducted with healthy control patients, pancreatitis patients as well as pancreatic cancer patients, with the use of nanoplasmon-enhanced scattering (nPES) assay a fast, sensitive, and specific method in biomarker detection. Convention Tumour Markers in Pancreatic Cancer Carcinoembryonic Antigen CEA CEA, is a glycoprotein, that is measured in a common blood test used for testing patients with cancer, including pancreatic cancer.   This will measure the amount of the CEA protein that is in the blood of a patient who may have cancer, and the CEA levels can be used to determine whether treatment is working or if the cancer is spreading.   A CEA level of 5 ng/mL, is considered a normal level of this protein, but there are several conditions that can alter the levels of the CEA in your blood, which is why this is not a valid biomarker in the detection of pancreatic cancer.5 CEA testing can be useful in regards to recurrent colon cancer as well seeing if treatment is successful.   Levels of CEA can be elevated due to smoking, as well as in other diseases such as Crohns disease.   Due to the unreliability of CEA levels in cancer, this blood test confirms that CEA is not a consistent biomarker for the early detection of pancreatic cancer. CEA is expected to be paired with other biomarkers, for early detection reasons.   When paired with CA19-9, there is an increase in detection for sensitivity and specificity, showing an improvement in diseases including pancreatitis as well as pancreatic pseudocyst.   Despite the improved results for pancreatic diseases, CEA is still not valid for the detection of pancreatic cancer, even when it is paired with another marker such as CA19-9.5 Carbohydrate Antigen CA19-9 Carbohydrate antigen (CA19-9) was discovered in 1981, and is considered a sialyl lewis a (sLea).9 CA19-9 is found on the surface cancer cell, expressed as a glycolipid and an O linked glycoprotein, and is related to the Lewis blood group antigens.3   Patients with Le (alpha beta +) or Le (alpha + beta -) blood group, express levels of CA19-9 in their blood, whereas approximately 5 10% of patients with Le (alpha beta -) blood group do not express CA19-9, limiting the use as a valid biomarker.9 Due to the low, and uncertain sensitivity of CA19-9, it is a poor interpreter of PDAC, therefore it is not a valued biomarker. CA19-9 is unable to differentiate between benign, precursor lesions and malignant conditions in PDAC patients, and it gives elevated results in many other gastrointestinal cancers.3   This blood test can show elevated CA19-9 levels in patients with other non-cancer diseases including pancreatitis and cirrhosis.3,9 The CA19-9 blood test can be beneficial in regards to knowing if a pancreatic tumour is secreting it, and to judge the efficiency of treatment, and look for pancreatic cancer recurrence.   A healthy patient will have a CA19-9 level of 0 37 U/mL, therefore with increasing levels of CA19-9, this could indicate tumour growth.3 For more accurate results, a PDAC marker needs to be discovered and paired with CA19-9, to increase the sensitivity and specificity in early detection.   With CA19-9 as the only marker, studies show it was only elevated in 50 75% of patients having PDAC, confirming that is not consistent as a biomarker and should not be used in diagnostic testing.3,9 Expressing elevated levels in other diseases such as benign jaundice, pancreatitis, and ovarian cancer, confirms the lack of consistency using the CA19-9 marker and that it cannot be used as an accurate indication of early pancreatic cancer detection.3 Emerging Biomarkers With the absence of reliability using the current PDAC biomarker, C19-9, it is a necessity to discover a biomarker with improved sensitivity as well specificity for the early detection of PDAC.   Recent studies suggest, that exosomes can be detected in body fluid such as blood, and they have potential as disease biomarkers.   Exosomes, found in blood plasma, need to be collected from healthy patients to obtain individual and pooled samples.   The collected blood plasma, will need to be separated, by centrifugation, to isolate the exosomes for further proteomic and quantitative studies.8 Isolation Methods Isolation of exosomes using the UC method, involves normal human plasma, and diluting it with PBS.   The sample will be differentially centrifuged, to eradicate cell debris, which is followed by UC.   The subsequent pellet, is washed in PBS, and filtered, and the filtrate was ultracentrifuged.   The resulting exosomal pellet, used for the study, will be resuspended in PBS.8 Using the EI isolation method, the plasma, is diluted in PBS and centrifuged.   The supernant is filtered, and the filtrate will be incubated using a blocking agent.   A microcolumn was placed in magnetic separators, where the column was rinsed with rinsing solution.   Beads were bound to the exosome, and were applied to the magnetic column.   The column will be washed with rinsing solution, and the immune captured exosomes were recovered by removing them from the column and placing them in a collection tube.   The exosome bound microbeads are washed to elute the exosomes, and centrifuged to obtain the exosomal pellet.   The exosomal pellet will be resuspended in PBS.8 Lastly, isolation using DG method, involved the exosomal pellet that was obtained from UC as well as normal blood plasma that was layered on iodixanol solution and centrifuged.   To the top of the tube, there were 12 fractions, with increasing densities.   The fractions are diluted with PBS and centrifuged, the resulting pellet was washed with PBS, centrifuged and resuspended in PBS.8 Western Blot and Microscopic Analyses The western blot method, shows the enrichment of the exosomal marker proteins.   Gel electrophoresis is used to separate and identify the different proteins.   The thickness of the band, indicates the amount of the protein that is present.   There is a labelled antibody, that is bound to the protein of interest.   AFM is used, to get a 3D image of the exosomal vesicle. Recent studies confirma that the exosomal markers CD9 and CD63 are enriched in exosomes purified using UC and EI methods.8 The study indicates that the UC method, had four exosomal markers whereas the EI method had only two exosomal markers, CD9 and CD63.   Transmission electron microscopy (TEM) and atomic force microscopy (AFM), were used on the isolated exomes, from the three exosomal isolation techniques.   In the DG sample, the TEM reported homogeneous vesicle, with diameter ranging from 40 100 nm, confirming the characteristics of exosomes.   The AFM produced a 3D image of the exosome, and after further analysis it was revealed that the exosomes had round membranous vesicle characteristics. LC-MS/MS Liquid chromatography mass spectrometry (LC-MS/MS), is a quantitative method used for the identification of proteins at the peptide level.   The first quadrupole is for the selection of the precursor and the second quadrupole is highly specific for detection.   In comparison to gas chromatography mass spectrometry (GC-MS), LC-MS/MS is not limited to volatile substances, it is better for the detection of molecules.   LC-MS/MS can produce many quantitative results, and has a high specificity and sensitivity. The study was carried out, using an LTQ Orbitrap Velos with a nanoelectrospray interface coupled to an Ultimate 3000 RSLC nanosystem and the LTQ Orbitrap Velos mass spectrometer operates using a nano -ESI spray.   The LC-MS/MS spectra are searched against the human protein database using MASCOT.   Equal amounts of protein from the three exosomal samples were separated, reduced, alkylated and digested with trypsin.   The DG sample had the highest number of protein identifications, followed by the UC isolation method.   Therefore, the western blotting, microscopy and MS results confirm that the DG isolation method is the most effective, in regards to isolating exosomes from blood plasma.8 Targeting with Gold Nanoparticles Malicious Exosomes The exosomes are formed from endosomal pathways, after they are fused from multivesicular bodies (MVBs) with plasma membrane.   The formation of malicious exosomes, also starts in the endosomal pathway.   The early exosome is formed from the migration from the cell periphery to the nucleus, by the formation of intraluminal vesicles (ILV).   The process interceded by exosomal complexes required for transport (ESCRT) and other proteins.   Late exosomes/ MVB, migrate to the periphery and fuse with the membrane, releasing the ILV, which are called exosomes.   The proteins, Rab GTPases, mediate the endosome migration.7 The malicious exosomes, are released from cancer cells found in the tumour microenvironment.   Exosomes play a role in variation and shaping of that tumour microenvironment.1,2,4,6,8 Malicious exosomes have potential as biomarkers, due to their stability in biological fluids including blood plasma.   There have been increased levels of circulating exosomes seen in several cancers including pancreatic cancer.1,6,7,8 Nanovesicles can be used to carry therapeutics, and have potential to limit cancer progression.1,7 The method consists of inhibiting the malicious exosomes biogenesis. Gold Nanoparticles The GNPs can be easily synthesised, as well they consist of a variety of shapes and sizes.   These nanoparticles exhibit intense light absorption and scattering, and they are deemed to be highly stable.1,7   They have potential in targeting, therapeutics as well as diagnostic capabilities. Regarding rapid tumour growth, a compressed lymphatic vessel will collapse causing lymph drainage, which will then allow for the nanosized molecule to be taken at the tumour site.7 This process will allow for passive targeting with nanosized molecules.   The cellular interest will be dependent upon the size and shape of the GNP.1,7 The tumour cells will overexpress their cell number receptors, which can be used for potential biomarkers.1,2,4,6,7,8 These cell surface receptors, will aid in the direction of the GNP to the tumour cells. Gold Nanoparticle Targeting The GNP will target malicious exosomes, by undertaking the malicious exosomes biogenesis with GNP specific targeting moieties as well as silencing moieties.7   Using antibodies to aim at the exosome for capture and selective retention.   Lateral flow immunoassay, will aid in exosome detection with CD9 and CD81 as antibodies, and CD63 with GNP.1,7 Therefore, GNP are being studied as a potential candidate for cancer therapy as well as for malicious exosome targeting.   The use of nanotheranostics to help quantify and inhibit the malicious exosomes. Sample Collection and Processing This recent study, developed a method for the purification of exosomes in blood plasma, as well as finding the EV concentrations in the plasma samples.   A three-probe EV capture was used, with a capture antibody that recognizes an EV membrane protein (anti-CD81), with antibody conjugated AuS and AuR to serve as two EV probes.   This EV capture was designed to form a plasmon, with the different GNP binding on an EV to improve sensitivity and specificity of EV detection.1   The study examined 59 pancreatic cancer patients, 48 pancreatitis patients, and 48 control patients, to see if early pancreatic cancer stage could be distinguished from pancreatitis patients and the control patients.1 Method The EV isolation consisted of cells grown in culture media, and washed with PBS.   The culture supernatants were collected and centrifuged to pellet cells, and centrifuged again to remove cell debris.   Concentrated with centrifugal filtering units, and centrifuged, the precipitates were collected and resuspended in PBS and centrifuged.   The resulting precipitates were collected and dissolved in PBS.   The ELISA assay, consisted of ninety-six well plates, which were incubated with antibody CD81.   The ELISA assay was analysed for absorbance, and the standard curve plotted the light absorbance versus the log10 EV standard concentration in pg/uL.1 The peptides were separated using Ultimate 3000 nano-LC, with an enrichment column as well as an analytical column.   The peptide fractions were analysed with Velos Dual-Pressure Linear Ion Trap mass spectrometer, and one MS scan, was followed by eight MS/MS scans. The nPES platform was constructed by filling sample wells with plasma sample or cell culture EV samples, followed by incubation and being washed three times with PBST and three times with PBS.   The sample wells were then filled with AuS and AuR PBST solution, and were incubated and washed three times each with PBST and PBS, respectively.   The sample wells were fitted with a cover slip and dark-field microscopy (DFM) was used for imaging.   The DFM images, that had image areas with brightness equal to 225 were selected, and the ratio of the image area to the whole image gave area ratios that were indicative to the nPES EV signal.1 A standard concentration curve was generated with a linear regression of nPES area ratio with log10 concentrations.1 SEM images analysed the images of GNP binding to EV, from EVs that were purified from human plasma.   The purified EVs were hybridized with anti-CD63-AuS and anti-CD9-AuR.   The SEM fields were analysed to calculate the total EVs, as well as the number of GNP-bound EVs per um2 of each assay. Proteomics and the Early Detection of PC An nPES was previously designed, for EV detection using GNP, that can scatter light at different wavelengths indicative to their shape and size.   Using both gold nanospheres (AuS) as well as gold nanorods (AuR), a plasmon is formed, increasing the scattering intensity.   With the plasmon, antibodies against CD9, CD81, and CD63 can capture and detect EV in a sample.1,7   AuS and AuR are detectable using dark field microscopy (DFM), and will form the complexes AuS-EV-AuR, AuS-EV and AuR-EV.   These complexes can be analysed using scanning electronic microscopy (SEM), examining the binding and distribution.   Following the pure preparation of EV samples, EV plasma was added to give the EV plasma standard.   The anti CD81 was incubated with the standard and two antibodies conjugated GNPs, AuS-Anti-CD63 and AuR-Anti-CD9, which exhibited ratios >0.35%.   A comparison was done with nPES and enzyme linked immunosorbent assay (ELISA), of the sensitivity and linearity of thei r EV values.   The nPES assays showed to be highly sensitive, requiring less plasma as well has exhibiting more advantages over ELISA in regards to measuring EV concentrations.1 Since CA19-9 is the only accepted pancreatic cancer marker that is not valid, pancreatic cancer derived EV marker is a more feasible biomarker due to the multiple factors that the pancreatic cancer cells express.   The nPES assay will quantitate tumour derived EV from blood samples, and one of the two EV specific GNP were replaced with one specific for the membrane protein.   LC-MS/MS proteomics, bioinformatics is used to identify trans-membrane proteins on EV PC (PANC-1 and MIAPaCa-2) and PDAC (BxPC-3).1 There were 128 membrane proteins identified, and 26 were expressed on EV.   The EphA2 showed the highest expression and is associated with cancer progression, metastasis, and prognosis.   The EphA2, was also not expressed by EV in HPNE. EphA2 was chosen as the potential marker, and CD81 and CD9 were chosen for EV capture.   The nPES was modified, using one capture antibody (anti-CD81) and two antibody-conjugated GNP probes (anti-EphA2-AuS and anti-CD9-AuR).1 The plasma EphA2-EV levels were higher in pancreatic cancer patients, in comparison to pancreatitis patients and the normal control (NC).   With the strong association between the circulating EphA2-EV and early stage pancreatic cancer, there is potential for EphA2-EV to be used as an early detection marker.1   The CA19-9 levels were increased in the pancreatic cancer patients in comparison to the pancreatitis patients and the NC, but the levels were not increased in the early stages of PC.   The receiver operating characteristic (ROC) curves, showed that the plasma EphA2-EV levels are promising in the classification of pancreatic cancer stages. The current EV analysis methods are tedious and lengthy for the isolation procedures, as will having volume requirements.   The nPES platform that has been studied, assimilates EV capture and detection with the use of the plasmon coupling effect, to have an increase in both detection sensitivity and specificity in small volume samples and fast sensitive biomarker quantification.   This EV nPES platform, can be generalizable for any disease state that has a specific EV marker.1  Ã‚   The nPES EphA2-EV blood assay shows substantial value regarding pancreatic cancer screening tests, due to being a rapid, accurate and non-invasive blood test for the early diagnosis of pancreatic cancer. Conclusions This review article explains the need to find a valid biomarker in the early detection of pancreatic cancer, as well as discussing how exosomes have potential to be that marker in the early detection process.1,2,4,6,7,8   The existing biomarkers for pancreatic cancer, are not valid markers in the early detection due to the lack of sensitivity and specificity that they exhibit when differentiating between benign and malignant stages.   The use of exosomes for the early detection of pancreatic cancer, shows potential as a biomarker, with the use of nPES platform.1 The platform allows for EV capture using plasmon coupling, which increases in detection sensitivity and specificity, which allows for the discovery of an ultrasensitive biomarker.   The nPES EphA2-EV assay could differentiate between pancreatic cancer patients (stage I and II) and pancreatitis and NC patients.1 The role of EphA2-EV, could help to improve early detection rates as well as improving patient outcome, and th is blood test is inexpensive, accurate and non-invasive.   This review involved proteomic and quantitative methods, to find a novel biomarker for the early detection of pancreatic cancer, and non-invasive nPES EphA2-EV analysis can aid in improving early pancreatic cancer detection and treatment. References Liang, K.; Liu, F.; Fan, J.; Sun, D.; Liu, C.; Lyon, C. J.; Bernard, D. W.; Li, Y.; Yokoi, K.; Katz, M. H.; Koay, E. J.; Zhao, Z.; Hu, Y. Nature Biomedical Engineering 2017, 1 (0021). Duxbury, M. S.; Ito, H.; Zinner, M. J.; Ashley, S. W.; Whang, E. E. Biochemical and Biophysical Research Communications 2004, 320 (4), 1096-1102. Jazieh, K. A.; Foote, M. B.; Diaz, L. A. Seminars in Radiation Oncology 2014, 24 (2), 67-76. Ansuini, H.; Meola, A.; Gunes, Z.; Paradisi, V.; Pezzanera, M.; Acali, S.; Santini, C.; Luzzago, A.; Mori, F.; Lazzaro, D.; Ciliberto, G.; Nicosia, A.; Monica, N. L.; Vitelli, A. Journal of Oncology 2009, 2009, 1-10. Ballehaninna, U. K.; Chamberlain, R. S. Tumor Biology 2013, 34 (6), 3279-3292. Melo, S. A.; Luecke, L. B.; Kahlert, C.; Fernandez, A. F.; Gammon, S. T.; Kaye, J.; Lebleu, V. S.; Mittendorf, E. A.; Weitz, J.; Rahbari, N.; Reissfelder, C.; Pilarsky, C.; Fraga, M. F.; Piwnica-Worms, D.; Kalluri, R. Nature 2015, 523 (7559), 177-182. Roma-Rodrigues, C.; Raposo, L.; Cabral, R.; Paradinha, F.; Baptista, P.; Fernandes, A. International Journal of Molecular Sciences 2017, 18 (1), 162. Kalra, H.; Adda, C. G.; Liem, M.; Ang, C.-S.; Mechler, A.; Simpson, R. J.; Hulett, M. D.; Mathivanan, S. Proteomics 2013, 13 (22), 3354-3364. Ballehaninna, U. K.; Chamberlain, R. S. Indian Journal of Surgical Oncology 2011, 2 (2), 88-100. Pancreatic Cancer https://www.cancer.org/cancer/pancreatic-cancer.html (accessed Mar 20, 2017). Eldorado by Edgar Allan Poe | Analysis Eldorado by Edgar Allan Poe | Analysis In the poem Eldorado, poet Edgar Allan Poe delivers a fundamental message that can be understood if carefully evaluated. Poe gives the account of a knight in search of a land called Eldorado, which holds riches and fortune. After much futile searching, the knights enthusiastic quest for treasure ends in death. The foremost theme of this poem is the desire for wealth and treasure. This theme is an influence from Poes life and the relevant Gold Rush of 1849 (Coad 60). The literary devices, symbols, relevancy, and personal experiences offer a deeper meaning to the poem than what lies on the surface. Poes skillful use of these elements helps to stress the ignorant desire humans have for wealth and fortune. The poem delivers a reflective moral issue many readers can, in some way or another, relate to. Poe uses the word shadow in each of the four stanzas of the poem, each stanza consisting of six lines. The third line in each stanza is where the use of the word shadow is introduced. Though the word occurs multiple times, it has a different meaning each time. The first shadow represents a literal shadow, a casting shadow of the sun. It could also be interpreted as happiness and sadness. The second shadow represents the shadow that has overcome the knights heart after much unsuccessful searching. The third shadow represents a live figure, possibly his or maybe an angel. And the fourth shadow figuratively refers to Valley of the Shadow (21). The fact the knight has grown old and weak, and must cross Over the Mountains Of the Moon, Down the Valley of the Shadow is seen as a symbol of the knights death, relating to the Biblical valley of death (19-21). Through Poes use of the word shadow and the period in which the poem was written, readers can understand Poes message. Poe uses the shadow in each stanza to convey his message. As the meaning of the shadow changes, so do readers emotional state. As he begins the first stanza, readers see a happy, gaily, bedighted knight who is enthusiastic about going on his search for gold. This start gives readers a sense of happiness and jolt of energy. His shadow could also be a foreshadowing of future events. However, Poe begins the second stanza with the word But. This contradictory word signals a shift between the first and second stanza and also a shift in emotion. The knight has become old, disheartened, and dismayed as the shadow is used in context to signal the emotional state of the knight. This signal causes readers to suddenly have a change in emotion; readers become sympathetic towards the knight. Poe continues to elaborate on the disappointment of the knight in stanza three. The knight encounters a live or possibly imaginative figure and asks the shadow where is Eldorado, reflecting on his hopeless jo urney in which he wasted his life. This figure could possibly be an angel providing guidance, an angel of death, or even himself. As the shadow replies to the question in stanza 4, readers are left with the idea that he has come to the end of his life and has died. With the closing of the poem, the audience can relate to the pain the knight feels. In all, the repetitive shadow becomes engraved in the readers mind, helping to sway the emotions. The life of the knight also provides a moral for people to learn. Poes moral in Eldorado is not to seek for riches on earth. The only true riches are the riches one receives after death. The knight in the poem seeks for physical riches for many years without any hope, leaving him disheartened and at the end of his life. When asked where Eldorado could be, the knight was told Down the Valley of the Shadow (21). This insinuation emphasizes the main point that true riches are found in Heaven, not earth, and any riches sought on earth leads to despair and death. As suggested by The Meaning of Poes Eldorado by the John Hopkins University Press, it can be argued Poe portrayed himself as the knight (Coad 60). Poe published his poem in 1849, the same year as his death. Like the knight, Poe had sought after an accomplished life, which he failed to do during his life. He was also unstable in the last years of his life. However, the knight most probably was a reference to the many prospectors of the California Gold Rush, which took place during the time the poem was written. The poem may have been Poes warning to the many prospectors that would experience the same hardships of the knight. Poes repetition of shadow and Eldorado and use of other symbols play an important part in his poem. It helps to further stress his main point. Other such devices Poe uses to communicate to his audience is through auditory and imagery senses. Poe uses aabccb rhyme scheme in the first three stanzas and xxabba rhyme scheme in the fourth stanza of his poem . Poes creatively written stressed and unstressed poem is one way Poe remarkably appeals to the readers auditory and imagery senses. The use of this rhyme scheme creates a thumpity, thump sound when read aloud, bringing the clattering of the horses trot to life. The symbols and rhyme scheme helps to immerse the reader into the scene of the poem and drives them to continue reading until the end. Eldorado is a poem by Edgar Allan Poe that has a stressed message to readers. It tells the story of a knight who traveled for a period of his life searching for a city of gold, Eldorado. It provides a message to all readers that true riches and happiness are only acquired through Heaven after death. If one attempts to search for wealth, in hopes happiness will follow, that person will come to the end of their life saddened and in despair. Poes use of symbols, rhyme scheme, and repetition brings life to his poem, which keeps the readers entertained and helps to convey his message. The poem brings light to the life of everyone and anyone searching for happiness and wealth on earth. Thus, Eldorado is Over the Mountains Of the Moon, Down the Valley of the Shadow, Ride, boldly ride . . . If you seek for Eldorado! (19-24).

Frankenstein Notes :: essays papers

Frankenstein Notes Observations: 1. We commonly refer to the enormous monster as â€Å"Frankenstein†, when in fact he was never given a name. 2. Many references are made throughout the story to other famous literary works, such as Milton’s, Paradise Lost and Coleridge’s, The Rime of the Ancient Mariner. 3. Victor is a seeker of knowledge; he seeks answers to what occurs in nature and the physical world. 4. Upon his arrival at the University, Victor puts all his time and energy into his studies; he even disregards his health and family. 5. Many gothic elements of the grotesque are found throughout this book. 6. The environment of the book is described as dark and eerie. 7. After the creation of his monster, Victor suffers a so-called â€Å"living torture† for the consequences of his actions. 8. The weather plays a big role in setting the overall tone of the book. 9. The idea that man is born good, but it is society and other pressures that create an evil in man is relevant and part of the romantic theme depicted in the story. 10. The central concern of the novel is the basic need for companionship. Humans seek other individuals for their mate, in which they can share a life-long relationship together. Vocabulary: 1. capacious: able to contain or hold much; roomy; spacious. 2. paroxysm: a sudden outburst as of laughter, rage, or sneezing; fit; spasm. 3. chamois: a small goat antelope of the mountains of Europe. 4. galvanism: electricity produced by a chemical reaction. 5. chimera: an impossible or foolish fancy. 6. dogmatism: dogmatic assertion of opinion, usually without reference to evidence. 7. lassitude: state or feeling of being tired and listless; weariness; languor. 8. mien: a way of carrying and conducting oneself; manner. 9. ignominy: loss of one’s reputation; shame and dishonor; infamy. 10. aiguilles: a peak of rock shaped like a needle. 11. hovel: a small shed for sheltering animals or storing supplies. 12. offal’s: refuse; garbage. 13. viands: food of various kinds; especially choice dishes. 14. vestige: a trace, mark, or sign of something that once existed but has disappeared. 1. Robert Walton is the narrator of the novel. The time period in which the story is told is in the 1800’s. 2. The characters of the story are Victor Frankenstein, the â€Å"monster†, Robert Walton, Alphonse, Caroline, Ernest, and William Frankenstein, Elizabeth Lavenza, Justine Mortiz, Henry Clerval, M. Krempe, M. Waldman, M. De Lacy, Felix De Lacy, Agatha De Lacy, Safie, Mr. Kirwin, and Margaret Saville. 3. The setting takes place in Europe. 4. The general themes of the novel are use of knowledge for good and evil purposes, the use of new technology in modern life, the treatment of the poor and uneducated, and the powers of nature and the human physiology.

All we need is love

All we need is love Love is a very deep feeling that goes with us in our life. Without love there is no true life and no meaning of life. From the moment we are born we are surrounded with love of our parents and other relatives and we love them back. First we love our mother – the first person we see in our life. You may say that in our babyhood it is an unconscious feeling, it is an instinct, but nevertheless it is true innocent love and affection. As we start sense the world we start feel love to father and other close people.We take and give this love s self-evident and can't even imagine our life without these people. Growing older we experience first love to somebody in kindergarten or at school. It is always pretty to kick at the little children attracted to each other. And it is a wonderful moment to realize that you are in love for the first time. In childhood and also in our adult life we also love our pets – cats, dogs, goldfish, tortoises etc. Our pets can a lways make us kind and happy. Have never understood people who don't love animals, and I am sure that every child should have a puppy or a kitten.Besides, care of domestic animals helps to bring up a conscious, responsible, attentive person. In our mature love we may love some persons, and we are very lucky if there is somebody who loves us back. Sure there can't always be mutual love, and we can't make somebody to love us as we do. But when we feel it, the world seems wonderful. Without a doubt love makes us stronger, happier, and more motivated. We get desire to become better for the person we are in love with, and to make good deeds. Love inspires everybody. Many poets, writers, artists, composers devoted heir works to beloved persons.If there was no love in our life there will be no outstanding works of art known all over the world. Sure it is a hard job to love someone, in spite of his/her imperfections, and the marriage build on love is the strongest. A person who does not lov e cannot be happy. He is usually grumpy, nervous, and strict. He cannot understand those who are experience this feeling. Feel sorry to such people because love is the most beautiful thing that can happen. I wish everyone to feel it, and I hope you and your close people love each other, and this love Will last forever.

Media: Celebrities

Coming from a Latin word celeber, the word celebrity means a person widely recognised by the public and the media, person who through his command in the public creates media attention and is widely covered. One of prerequisite of a person being celebrity is fame, but that has to be associated with the media attention. Mass communication play a vital role in making someone celebrity as the person can be famous and well known but if the media is not piqued by that person, then the person cannot reach the celebrity level.People become celebrities in accordance to their professions, what they do to the public; this can be politicians or Chief Executive Officer (CEO) of certain large organisations such as Bill Gates, who stepped out of it few months ago, but still a celebrity. Celebrities to be in that status with the help of media are being known across the world, meaning can be famous not only in their countries but even outside their countries, and this category caters especially to th e politicians and actors and actresses.Religious leaders example Bishop Desmond Tutu for his involvement in freedom fight in South Africa and cultural leaders such as Dalai Lama of China for his outstanding performance in fighting for the rights of Tibet people; these people can be famous not only in their countries but not abroad due to their extensive coverage in the media. Excellence in sports also can make people famous not only in their countries but even worldwide such as Serena and Venus Williams are known globally due to their excellent performance in Tennis sport.Apart from sports, some people become celebrated due to their nature of their professions especially the highly paid ones which make them in contact with the media in most of their work schedules. These include people in the media presenters who are highly paid and well respected due to their exceptional work to the public, interior decorators, movie producers and sports coaches to mention a few who have caught the media attention and have been covered in mass entertainment.Some people become celebrities due to their family backgrounds, especially if some member of family were and are celebrities. This is found mostly in families engaged in music and movies industries like Jacksons, Winans and Osbournes while for politician families we can say Bushes, Clinton and Kennedys in United States of America (USA).Nevertheless, in accordance with the definition of celebrity that is something that has to be commanded by a person both in public and through the media, most of people must asking themselves how these people have earned the celebrity title. Due to this some scholars did start studying this celebrity phenomenon, by looking at the celebrity characteristics, psychology and even the interaction with the members of public, which makes people sometimes get too carried away with the celebrity worship. In America the number of people worshipping celebrities keeps on going up which has even affected people psychologically. Famously the syndrome now is known as celebrity-worship syndrome (CWS), the term invented by media but psychologists call it Celebrity Worship Scale (WCS).This situation has made people to look closely to the whole issue of celebrity, its attachment with the society and how people are reacting to it. Why people acting they way they do to the point of stalking celebrities. In survey conducted in USA, more people are affected by CWS which has led to people seek psychological help as Kate Douglas portrayed in her article when you wish upon a star, â€Å"Psychologists are starting to suspect that worshipping celebrities is the top of a slippery slope that leads to depression, anxiety and psychosis.† (Douglas Kate, When you wish upon a star, 2003).The effect is not only to the celebrities themselves, but the public also get affected by the whole issue of celebrity. Most of people wishing to be stars so as to be treated like star especially due to the media coverage these people get. Studying celebrity academically can help the society understand both parts that means celebrities themselves and the public which is affected by the concept of celebrity.The effect is much grave especially to the adolescents who spend most of their time wishing to be star, having cuttings and pictures of stars in their rooms and things they possess. Yes teenagers can think about celebrities as it is bring sense of social attachment, but not that excessively which affect the way of thinking of these teenagers or even adult for that matter which sometimes experience difficulties when encountered with problems.The effect if not dealt with early leads to more effects such as disorder to the worshipers like stalking celebrities or disillusion stalker gets that celebrity is love with him/her. The situation apart from stalking stars and celebrities, some of fans are copying what these celebrities are doing even if are bad things. This condition has sparked a lot of academics into researching the issue of celebrity and looking deeply for its effects to the society.An example that can be used here is the case of John Warnock Hinckley, Jr. who stalked Judie Foster after watching the Taxi Driver movie. He was seeking Judie’s attention to the point of following her to another state, the situation led into Hinckley attempting to assassinate President Ronald Regan in 1981 so as to catch Judie’s attention. He was later charged but found not guilty on basis of insanity and admitted at Saint Elizabeth in Washington DC. With experience like this studying celebrity should be taken into account as to understand psychological effects that associate with celebrities.The effect does not end to the fans only, but celebrities too are affected by the whole idea of being celebrity. Celebrities sometimes are also affected with the way society take them, their image and sometimes they are supposed to do things which is not in their heart simply be cause they have to comply with public especially in maintaining good image. The good image does not necessarily be the star image but sometimes can be the image of the organisations they are representing. This notion tend to make celebrities pretend sometimes especially in front of members of media and photographers.In his book The Image (1961), historian Daniel Boorstin criticised the way American society was living where it was heading concerning public image. The image that keeps on being fabricated and staged by the influential people especially politicians, movie stars and other celebrities. â€Å"Just as there were now counterfeit events, so, he said, there were also counterfeit people – celebrities – whose identities were being staged and scripted, to create illusions that often had no relationship to any underlying reality.† (Boorstin Daniel, The Image, 1961). The tendency, which has forced some of celebrities to get depressed and frustrated, hence seeki ng medical help which has led to some psychologists researching into the matter.The good example here can be referred to an icon which has made history in Hollywood, Marilyn Monroe who died by overdose from drugs. Marilyn was under chronic depression which made be constant contact with psychologists but later she paid with her life. Though not most of celebrities in movie industry die by overdosing themselves, but most of them undergo depression, which later on lead into drug addictions.Not only movie superstars experience the other side of the coin, which is depression even politicians and other celebrities do. The good example being Abraham Lincoln (1809-1865), the President of America in 1800s has also underwent severe depression too which was claimed to be associated with a horse blow he got when he was 10 years of age, while it sometimes associated with the death of his first love and mother. The only therapy in those days was through churches in Christian moral treatment but L incoln managed to overcome his depression by engaging himself in politics which later on he become a well respected one.Despite the fact that movie icons get into addictions, not all celebrities are like that as there is difference between these two categories. Film star is the one that get his/her stardom due to the participation in movie industry but celebrities can be from any field apart from film industry. Taking examples of film stars the list is long from Tom Cruise, Will Smith, Judie Foster, Meg Ryan and Nicholas Cage to mention a few.In conclusion, it is worthy studying celebrity issues, as it is the only way of understanding the interactions between celebrities and their surroundings, the people they mingle with, how they maintain their personalities and images to the public. Many celebrities are being used to advertise products such as David Beckham, Roberto Carlos and others like Christina Aguilera in Pepsi advert. This advertising involves media and through that people tend to question the authenticity of the products displayed, hence lead to more research on them.Apart from advertisements, studies can be done to the people around celebrities, how are they interacting with them and what effects do they get, but all in all it is worthy a study.Reference:Boorstin Daniel, The Image: A Guide to Pseudo-Events in America, 1961Douglas Kate, When you wish upon a star, Newscientist, issue 2408, August 2003www.mindhacks.com/blog/2006/08/star_struck.html

Love Story Essays

Love Story Essays Love Story Essay Love Story Essay John and Mary was so love in each other, Mary never knew that John would change her life so much, since she got in love with him. They were like Romeo and Julie together. For every day that goes, their love gets bigger and bigger, they came so closer to each other. Every day and night, they spent their time together; there was not a single day when they were not together. They could not live without each other. John was so romantic to Mary, he spoils her with flowers and chocolates, he gave her the love that no one else was been able to give.They had been together for more than 3 years. John and Mary graduates at the same time, and then they bought together a very big house, they was happy together. Their love was so strong; there was nothing that could separate them. One day John and Mary invited their both parents on a dinner. That night every one of them was happy, they was having a good night all of them. They was dancing and singing all together. John and Mary’s parents w ere so happy for their children.They were always wishing for them to married one day. Suddenly John stood up, and and held a speech to Mary, he told how much he loved her. Suddenly he stood up and held a speech to Mary; he told how much he loved her. John knelt for Mary, and came up with the most beautiful diamante, and so he asked Mary if Mary wants to marry him. Mary says yes, and then they live a happily life. To – delt eksamen. Lydside- BilledE- Ideudvikling- klipning-Casting .

Free Essays on Ballad Of Birmingham

Dudley Randall’s â€Å"Ballad of Birmingham† describes the events of one mother’s tragedy. This poem is a literary ballad. It tells the story of what happened in Birmingham. The â€Å"Ballad of Birmingham† refers to the day in 1963 when four black children were killed when the 16th street Baptist Church in Birmingham, Alabama was bombed. This poem is a literary ballad. It has a rhyme scheme of abcb defe. There are two speakers in the poem both the mother and daughter. Through conversation we can get a sense of what the speakers are thinking and feeling. In this poem a little girl asks her mother if she can go and march for freedom in the streets of Birmingham. Her mother told her she couldn’t because, â€Å"the dogs are fierce an wild, and clubs and hoses, guns and jails, aren’t good for children.† The girl insists on going but her mother will not let her. Her mother tells her she should go to church and sing in the choir instead. The daughter goes and her mother smiles because she knows she is in a sacred place. The mother hears an explosion; she races through the streets to the church were all she found was the shoe her daughter wore. This poem has a strange irony to it. A mother tells her daughters she cannot go and protest for it is too dangerous. She tells her to go to church instead and sing in the choir. Little does she know something so tragic as a bombing could happen at a place that is suppose to be so sacred. The ironic part is the daughter would have been safer marching the streets, but her mother did not want her to go because she thought is was dangerous. In conclusion, I thought this poem was very good. I liked the way the author told the story through conversation. It described very well what was happening. We can get a sense of what seems to be a good is not always so. Sometimes what we think may be a better choice may not be true.... Free Essays on Ballad Of Birmingham Free Essays on Ballad Of Birmingham Dudley Randall’s â€Å"Ballad of Birmingham† describes the events of one mother’s tragedy. This poem is a literary ballad. It tells the story of what happened in Birmingham. The â€Å"Ballad of Birmingham† refers to the day in 1963 when four black children were killed when the 16th street Baptist Church in Birmingham, Alabama was bombed. This poem is a literary ballad. It has a rhyme scheme of abcb defe. There are two speakers in the poem both the mother and daughter. Through conversation we can get a sense of what the speakers are thinking and feeling. In this poem a little girl asks her mother if she can go and march for freedom in the streets of Birmingham. Her mother told her she couldn’t because, â€Å"the dogs are fierce an wild, and clubs and hoses, guns and jails, aren’t good for children.† The girl insists on going but her mother will not let her. Her mother tells her she should go to church and sing in the choir instead. The daughter goes and her mother smiles because she knows she is in a sacred place. The mother hears an explosion; she races through the streets to the church were all she found was the shoe her daughter wore. This poem has a strange irony to it. A mother tells her daughters she cannot go and protest for it is too dangerous. She tells her to go to church instead and sing in the choir. Little does she know something so tragic as a bombing could happen at a place that is suppose to be so sacred. The ironic part is the daughter would have been safer marching the streets, but her mother did not want her to go because she thought is was dangerous. In conclusion, I thought this poem was very good. I liked the way the author told the story through conversation. It described very well what was happening. We can get a sense of what seems to be a good is not always so. Sometimes what we think may be a better choice may not be true....

Animal Farm Essay Example for Free (#9)

Animal Farm Essay Animal Farm by George Orwell is an allegory written in 1943. It was also made into a TV film version in 1999 directed by John Stephenson, produced by Greg Smith and Robert Halmi and distributed by Hallmark Films. Animal Farm is a deceitfully simple story about a group of farm animals who are tired of living in a dystopia caused by humans. They rebel and create their own way of life, only to find themselves back in a dystopia caused by animals. The film follows the plot line of the novel closely but changes some major details. While the film and the novel Animal Farm are basically one in the same and have similar plot lines, the film had less detail, while the novel was thoroughly detailed. The differences between the film and the novel were points of view, exposition and major plots. Orwell tells the story of Animal Farm through a third person, omniscient point of view. The narrator is never involved in the action of the story, but knows everything. This point of view allows readers to see into the minds of the characters and understand their motivations. The film is told by a narrator, a character in the novel, Jessie. It explains the film in a way that she sees everything occurring. It also stops most of the dialogue between the animals and they don’t really talk like they do in the novel. Another difference between the novel and film is the exposition, which gives background information on the plot. In the novel, some of the events that occur in Animal Farm’s exposition play important roles later on in the novel. In the novels exposition, Orwell describes many of the animals that are important to the novel. In the films exposition, very little time is spent on developing the characters of the important animals. Also, the song Beasts of England is not sung in the exposition, unlike the novel, this song plays a very pivotal role later on in the novel. In the film, they don’t know the characters very well and the animals don’t really sing it, they hum it. This takes away from the mood of the song. The movie is merely an adaptation of the novel into film, so almost all the events that take place in the novel will take place in the film. Another difference between the novel and film is the major plot differences. The novel and film follow the same plot line but there are some major differences. In the novel, Old Major died about 3 days after his speech from natural causes. While in the film, Mr. Jones shoots Old Major minutes after his speech, while they’re reciting the Beasts of England song. In the novel, all of the animals could speak while in the film it was arrated by Jessie which cut the dialogue of most of the animals. The end of the film and novel differ greatly. In the novel, the animals are sadly dominated by Napolean. But in the film they somehow overthrow his power and finally bond together for another attempt at a utopia. The film covered major ideas but missed some details, characters, and small stuff that made the novel so interesting. It’s quite apparent that there are many significant differences between Animal Farm the novel and the film. There are a number of differences between the use of point of view, the exposition, and the major plots. Animal Farm is a simple story about a group of farm animals who overthrew their human dictators and their animal counterpart who dictated them also. The novel was very detailed and had many characters which made it very interesting. While the film had less details, and characters which made it a little dull, and boring. These are my comparisons of the film and novel called Animal Farm. Animal Farm. (2017, Feb 02). We have essays on the following topics that may be of interest to you

Introduction to Globalisation Coursework Example | Topics and Well Written Essays - 2000 words

Introduction to Globalisation - Coursework Example Indeed, a number of individuals warn that it is a huge mistake to â€Å"carry into the study of globalization the kind of view of culture that we inherit from the conventional analysis of the national society† (Benyon and Dunkerley, 2000, p. 13). Global Culture Conceptualizations Most of people such as journalists and academics use the term global culture and it is evident that there are different understandings of â€Å"culture† regardless of the different meaning devoted to the phrase â€Å"global culture.† There are different conceptualizations of global culture. First, global culture emphasizes spatialization and plurality. All cultural forms or different cultures are categorized based on their differences from one another. The cultural result of different individuals from some parts of the world which through the processes of electronic communication, migration, come to represented in a particular place. Cultural practices and form, which were characteristic of one region or location, have now been diffused in many different regions of the world. Plurality and spatialization are also emphasized by the non-isomorphic and multi-centred flows around the world. As an assortment of cultural phenomena or artefacts from different regions of the universe are now in one place; previously, they were thought as not belonging there, but now, they are perceived to be there (King, 2004, p. 26). Secondly, global culture emphasizes the deconstruction of the country state. Bodies of knowledge, lifestyles, conventions, and sets of practices have grown in ways through which they have become independent of the nation-states (King, 2004, p. 26). Global culture is seen in the forms of arts and the media, emerging from different regions and nations which are diffused across national borders. Global culture in this context sees the globe as a finite, inevitable bounded space, a place in which all the collectivities and the nation-states are drawn upon inevita bly. Thirdly, global culture emphasizes American cultural imperialism. Global culture is mainly considered as an American cultural imperialism. This is because the American commodities, malls, fast food, and media culture are developing a new global culture that is extremely the same on all continents (King, 2004, p. 27). Fourthly, global culture emphasizes a new or a homogenized system of culture. The surfacing of a new collection of globally shared practices and images, and an influenced condition of universality is mainly attributed to the idea of global culture. A completely new system of culture has emerged from the diffusion of cultural beliefs, practices, and values in the world, and this has taken a new attribute which has changed in the process. Therefore, global culture is a sole homogenized system of importance. Lastly, global culture emphasizes planetary. Global culture is a practical impossibility; however, it is possible in the context of inter-planetary terms. A globa l common culture was created as a reaction to the supposed threat to the continuous viability of life on the world through some ecological catastrophes (King, 2004, p. 27). Is There a Phenomenon Such As Global Culture? Does global culture really exist, and if it does, then what is it? The most tangible and obvious form of cultural globalization is the Western media products. These products include (a)

Career Strategy of Financial Analyst Research Paper

Career Strategy of Financial Analyst - Research Paper Example The present research has identified that as the company’s financial decisions and competencies depend on the results produced by the financial analysts, the job roles shared by these professionals are of immense significance and subjected to their proficiencies in dealing with numerical complexities apart from ethical dilemmas. Observably, the occupation that researcher has chosen is of a financial analyst, which basically owes to his skills and abilities along with academic credentials, deemed to suit this particular job profile. However, apart from the fact that researcher finds himself suitable for this particular profession, there are also certain other reasons that have altogether encouraged me to choose this particular career option. Contextually, there are certain key features associated with this particular profession, which further took the attention. Notably, the profession of a financial analyst has become quite widely established in the recent years and is further expected to rise in the coming years owing to the rising need for companies to gain financial competencies and advantages thereupon. This increasing level of popularity, as well as respect associated with the selected profession, has attracted researcher’s attention towards the same. Again, it has also been noted that the scope for this particular occupation is quite wide as the services offered by a professional associated with this particular profession is needed by various business units to conduct their business operations with adequate ease and confidence based on the realistic financial information.

Policy Development Paper Essay Example | Topics and Well Written Essays - 2750 words

Policy Development Paper - Essay Example As the essay discusses innocent people are given incentives and they fall in traps of agents who smuggle them illegally in countries and then exploit them. Poverty in developing countries is one of the reasons why human trafficking is increasing every day. Strict policies and law enforcement is required so that this abuse of human life could be stopped. This paper declares that human trafficking is defined as transportation, recruitment or harboring of a person, by deception, fraud, force or by giving incentive to a person, for the purpose of exploitation. Human trafficking is very common is developing countries where people are giving incentives of employment and are transported legally or illegally into developed countries where they are exploited. The impact of human trafficking on human society is disastrous. People who are transported in the country are kept in bondage labor. They are not allowed to use their passports so they cannot leave the country. We can say it is a form of modern slavery. These people are deprived of their civil rights and forced to undesirable activities. Women are mainly the victims of human trafficking and they are usually used for prostitution. Prostitution is illegal in most countries so girls from third world countries are brought to the developed world in hope of employment and later they are force fully used for prostitution purposes. These girls are not allowed to leave the country and criminal syndicates earn money from the work of these girls. A number of diseases can also spread in the country due to prostitution of trafficked women. In United States people have a fair bit of knowledge about sexual diseases but these girls come from backward societies so they have little or no idea of sexual diseases and their prevention. This makes these girls more prone to sexual diseases then other girls in the same business. Also they cannot go to hospitals because of their lack of identity so they are forced to live with it. These girls can transfer these diseases to their customers and in this way sexual diseases spread through prostitution. Human trafficking is harmful for society because trafficked people are used to fuel the illicit activities of the criminal groups. These people usually have no record of their existence so under coercion they perform activities like drug smuggli ng and prostitution. These crimes are fueled by people who are brought in the country by human trafficking. These people are easy targets because they are threaten and in turn they do anything their ‘masters’ want them to do. Bondage labor is another way in which human trafficking victims are exploited. They are used for producing a variety of products in factories or are made to work in mines (Penketh, A. 2006). Victims of human trafficking are very good workers because they are very cheap and they can even perform hazardous jobs. Also there is no need for insurance benefits or other benefits for these workers. The products produced by these victims are sold at low prices and competitive advantage is achieved (Penketh, A. 2006). Human trafficking also impacts human society by reducing employment opportunities for people of the country. Trafficked individuals are cheap labor so they are preferred by industries where manual labor is

Confederacies and Chiefdoms Essay Example | Topics and Well Written Essays - 1250 words

Confederacies and Chiefdoms - Essay Example   There were three main confederacies that inhabited the Eastern North America, namely the Hurons, the Iroquois and the Powhattans (Johnson & Smith, 2003). The three confederacies took the form of having one single leader who was in charge of different tribes or communities that had been united to form a confederacy. The confederacies were mainly found in the regions of Southern Ontario, near lakes Ontario and Erie, where the Huron confederacy occupied, while the Iroquois Confederacy occupied the central New York region and the Powhattans occupied the Chesapeake regions (Johansen, 2005). On the other hand, the chiefdoms were organizations of a single community under the leadership of their chiefs, who wielded much authority and powers over the people and established informal government structures, with their aides under them, who were responsible for overseeing the implementation of the chief’s authority by the different sections of the community. The chiefdoms occupied the major river ways of the Mississippi River hence their being referred to as the Mississippian chiefdoms (Milner, 2006). The advantages in both forms of political organization is that the coming together of tribes and communities gave the political organizations the strength to fight against their enemies as opposed to when they could fight as single tribes or communities. However, the disadvantage is that the political organizations allowed for the leaders to exploit their subjects since their word was the authority.   Therefore, the subjects had to share the spoils of their hunting, gathering and agricultural exploits with the leaders, through paying such exploits as tribute to the leaders (Milner, 2006). The population estimate of the confederacies and the chiefdoms in the eastern North America region has been the subject of controversy between archeologists. However, there is an agreement between the archeologists, based on the archeological artifacts that have been discovered in this region, that hunting and gathering was the main social and economic activity of the people, while

Viruses Research Paper Example | Topics and Well Written Essays - 1250 words

Viruses - Research Paper Example There are millions of types of viruses present in the world. A few thousands have been explained and studied in detail. Viruses can survive in severe and extreme conditions of temperature, pressure and atmosphere and hence cannot be easily destroyed or eliminated from the environment. Viruses can be found in almost all environments on earth. Isolated viruses are not living organisms because they cannot reproduce, grow or multiply unless they are present in a human or animal cell. The virus attacks the human, animal or plant cell, takes over the controlling and mechanism of the cell and starts producing products that are harmful for the body. The infected cell will now produce harmful products instead of its usual products (Mandal 41-76). Viruses are of various shapes but the basic structure of a virus always is composed of three parts. The nucleic acid is the main part of a virus and it is either a DNA or RNA. It is responsible for giving a virus its unique characteristics and helps to reproduce. The nucleic acid is protected by covering made from protein which is called the capsid; its purpose is to protect the nucleic acid from any sort of harm. The lipid membrane is a layer which is present over the capsid and is meant for protection. However this layer is not necessarily present in all viruses. Viruses can be transferred from organism to organism in different ways. Either the various can enter the body through direct contact with the organism contaminated with the virus. Some flying insects can carry the virus and transfer that virus to other organisms. Insect bites can also lead to a transfer of virus from one body to another. Contaminated food and water can also lead to the transfer of viruses. Viruses are responsible for a number of diseases like flu, cough, fever, measles, polio, hepatitis, yellow fever, small pox, Human immunodeficiency virus, rabies, influenza, diarrhea, etc. Among these diseases some are easily curable through regular medications and precautions but some of them are extremely difficult to take care of; the treatment is usually very expensive and besides the cost it is usually not sure that the medications will prove beneficial or not. Some of the diseases caused by viruses even do not have a cure and they ultimately lead to the death of the suffering person. Viruses can also cause certain types of cancer. For some of the diseases caused by viruses of which a proper cure is not present, the people are advised to take particular vaccines in order to keep themselves protected from the viral attack. By the use of vaccines the human body builds up the immune system to fight against any such viral attack and in this way the virus fails to attack the human cell and thus the human remains protected from those diseases which have no proper cure and are considered as life threatening diseases. The vaccines help develop antibodies in the human so that whenever such viruses are encountered by the human cells they can devel op antibodies to fight away the virus. In the earlier times when there were no vaccines many people used to die because of these incurable diseases but with the development of vaccines death rates have considerably reduced due to these diseases. The humans during the starting years of their lives are made to take vaccines against a number of viral diseases that are practically incurable in order to protect

Policy Development Paper Essay Example | Topics and Well Written Essays - 2750 words

Policy Development Paper - Essay Example As the essay discusses innocent people are given incentives and they fall in traps of agents who smuggle them illegally in countries and then exploit them. Poverty in developing countries is one of the reasons why human trafficking is increasing every day. Strict policies and law enforcement is required so that this abuse of human life could be stopped. This paper declares that human trafficking is defined as transportation, recruitment or harboring of a person, by deception, fraud, force or by giving incentive to a person, for the purpose of exploitation. Human trafficking is very common is developing countries where people are giving incentives of employment and are transported legally or illegally into developed countries where they are exploited. The impact of human trafficking on human society is disastrous. People who are transported in the country are kept in bondage labor. They are not allowed to use their passports so they cannot leave the country. We can say it is a form of modern slavery. These people are deprived of their civil rights and forced to undesirable activities. Women are mainly the victims of human trafficking and they are usually used for prostitution. Prostitution is illegal in most countries so girls from third world countries are brought to the developed world in hope of employment and later they are force fully used for prostitution purposes. These girls are not allowed to leave the country and criminal syndicates earn money from the work of these girls. A number of diseases can also spread in the country due to prostitution of trafficked women. In United States people have a fair bit of knowledge about sexual diseases but these girls come from backward societies so they have little or no idea of sexual diseases and their prevention. This makes these girls more prone to sexual diseases then other girls in the same business. Also they cannot go to hospitals because of their lack of identity so they are forced to live with it. These girls can transfer these diseases to their customers and in this way sexual diseases spread through prostitution. Human trafficking is harmful for society because trafficked people are used to fuel the illicit activities of the criminal groups. These people usually have no record of their existence so under coercion they perform activities like drug smuggli ng and prostitution. These crimes are fueled by people who are brought in the country by human trafficking. These people are easy targets because they are threaten and in turn they do anything their ‘masters’ want them to do. Bondage labor is another way in which human trafficking victims are exploited. They are used for producing a variety of products in factories or are made to work in mines (Penketh, A. 2006). Victims of human trafficking are very good workers because they are very cheap and they can even perform hazardous jobs. Also there is no need for insurance benefits or other benefits for these workers. The products produced by these victims are sold at low prices and competitive advantage is achieved (Penketh, A. 2006). Human trafficking also impacts human society by reducing employment opportunities for people of the country. Trafficked individuals are cheap labor so they are preferred by industries where manual labor is

Viruses Research Paper Example | Topics and Well Written Essays - 1250 words

Viruses - Research Paper Example There are millions of types of viruses present in the world. A few thousands have been explained and studied in detail. Viruses can survive in severe and extreme conditions of temperature, pressure and atmosphere and hence cannot be easily destroyed or eliminated from the environment. Viruses can be found in almost all environments on earth. Isolated viruses are not living organisms because they cannot reproduce, grow or multiply unless they are present in a human or animal cell. The virus attacks the human, animal or plant cell, takes over the controlling and mechanism of the cell and starts producing products that are harmful for the body. The infected cell will now produce harmful products instead of its usual products (Mandal 41-76). Viruses are of various shapes but the basic structure of a virus always is composed of three parts. The nucleic acid is the main part of a virus and it is either a DNA or RNA. It is responsible for giving a virus its unique characteristics and helps to reproduce. The nucleic acid is protected by covering made from protein which is called the capsid; its purpose is to protect the nucleic acid from any sort of harm. The lipid membrane is a layer which is present over the capsid and is meant for protection. However this layer is not necessarily present in all viruses. Viruses can be transferred from organism to organism in different ways. Either the various can enter the body through direct contact with the organism contaminated with the virus. Some flying insects can carry the virus and transfer that virus to other organisms. Insect bites can also lead to a transfer of virus from one body to another. Contaminated food and water can also lead to the transfer of viruses. Viruses are responsible for a number of diseases like flu, cough, fever, measles, polio, hepatitis, yellow fever, small pox, Human immunodeficiency virus, rabies, influenza, diarrhea, etc. Among these diseases some are easily curable through regular medications and precautions but some of them are extremely difficult to take care of; the treatment is usually very expensive and besides the cost it is usually not sure that the medications will prove beneficial or not. Some of the diseases caused by viruses even do not have a cure and they ultimately lead to the death of the suffering person. Viruses can also cause certain types of cancer. For some of the diseases caused by viruses of which a proper cure is not present, the people are advised to take particular vaccines in order to keep themselves protected from the viral attack. By the use of vaccines the human body builds up the immune system to fight against any such viral attack and in this way the virus fails to attack the human cell and thus the human remains protected from those diseases which have no proper cure and are considered as life threatening diseases. The vaccines help develop antibodies in the human so that whenever such viruses are encountered by the human cells they can devel op antibodies to fight away the virus. In the earlier times when there were no vaccines many people used to die because of these incurable diseases but with the development of vaccines death rates have considerably reduced due to these diseases. The humans during the starting years of their lives are made to take vaccines against a number of viral diseases that are practically incurable in order to protect

Reading and Comprehension Essay Example for Free

Reading and Comprehension Essay Read 8 Secrets to a Knockout Business Presentation using the SQ3R method. Answer the following questions to assess how well you followed the SQ3R method, and whether it helped. Note: Your grade for the assignment will depend on the quality and honesty of your responses and not on how successful you felt you were. ? What was the main point of the written piece? ? What did each section deal with? ? What questions did you ask yourself as you were reading? ? How can you change your note taking skills for the future? ? What would you do to retain this information for later use? ? How might the SQ3R method help you improve your reading comprehension and retention skills? Gen/105 Week 7: Reading and Comprehension Project 1. The main point of this written piece was to tell the reader what the eight most successful secrets were to delivering a knockout presentation in your business affairs. A lot of people at companies just make boring PowerPoint slides and it has so much irrelevant information that the point of the meeting is masked by a weak presentation. This article shows what to do and how to make a great presentation. 2. Each section of this paper dealt with a new and exciting way to capture the attention of a viewer of your business slides. The writer states to â€Å"dig deep† by adding new information and giving more to the viewer. â€Å"Avoid Info overload† shows that too much information can be detrimental to a project, people can bored and wander off. In the section â€Å"Practice Delivery†, it talks about how to memorized your speech and practice what you are saying. This will avoid mistakes, mishaps and fumbling with words. Also, the writer says to â€Å"forget comedy†, by leaving the humor out the project is more professional and shows that you are serious. By â€Å"pick powerful props† shows your audience that memorable ideas and notions can be obtained by using props, so the audience can remember ideas and thoughts associated with the presentation. Another secret is to â€Å"minimize you†, this means take out information relating to you or the business, because people already know what this information is. It waste space and time, and people can get sidetracked. â€Å"Speak the Language† notes that speaking as you always do will help minimize confusions with acronyms and abbreviated words. Be professional but make sure everyone can understand what is been said. Last but not least, â€Å"simple slides† states that you should use slides in your presentation to highlight important information and key words, don’t let the slides overrun the presentation. 3. The questions that came to mind when I was reading was significant. They dealt with how to maximize information during presentations and how do I apply material that are useful in my projects. I don’t want to use unnecessary information that is irrelevant. I also asked myself if using pictures and props were a good idea. I found out that these two tools are necessary to keep the audience engaged in what you’re talking about. 4. I feel like that I have great note taking skills. I always note key words and phrases. If I have a long or difficult reading I always break it down in paragraphs and take notes on key sentences. I also use an outline format which helps greatly. It is almost like the article written in my own language so I can understand it better. I always use my notes to go over information instead of trying to re-read an entire article to find important facts. 5. I will use notes to retain this information for later use. My notes can be very well written as well as the reading, with the same information available. I always keep notes to look over for extra information and key points. 6. I think the SQ3R method does help my reading and comprehension skills improve. By skimming the article I mentally note key words and phrases. I can see how each paragraphs ends and if there are any vocabulary words noted. Noting questions is helpful as well. Keeping in mind question I would ask about the article will help me find an answer to it within the paper. I believe the method does help a lot especially when it comes to larger papers or article that I need to comprehend.

Society of the Spectacle and War Photography

Society of the Spectacle and War Photography Discuss contemporary war photography in relation to Debords work on the Society of the Spectacle. Society of the Spectacle written by Guy Debord and published in 1967 at the height of the Vietnam war argues that the world has been overtaken by the notion of spectacle. Debord describes what the spectacle comprises of (in several numbered paragraphs); he says that, â€Å"In societies dominated by modern conditions of production, life is presented as an immense accumulation of spectacles. Everything that was directly lived has receded into a representation.† (#1) Debord is stating that life in the modern age has become fixated on reality as representation (i.e. by the media) real life experiences have been substituted for experiences that are digitally lived. Debord goes on to say that â€Å"the spectacle presents itself simultaneously as society, itself as part of society, and as means of unification. As part of society, it is the focal point of all vision and all consciousness. But due to the very fact that this sector is separate, it is in reality the domain of delusion a nd false consciousness: the unification it achieves is nothing but an official language of universal separation†¦the spectacle is not a collection of images; it is a social relation between people mediated by images.† (#3-4) With the rise of new media and the explosion of 24-hour news and reality television, it would seem that the existence of the spectacle becomes self-evident. Mass amounts of human beings are directed to gaze at what has become a global common culture, news and entertainment. For Debord, the spectacle is a tool of pacification and depoliticization; it is a â€Å"permanent Opium war designed to force people to equate goods with commodities and to equate satisfaction with a survival that expands according to its own laws†¦Ã¢â‚¬  the spectacle distracts from the most urgent task of real life. (#44) Debord argues, our sense of reality is nothing more than an immense accumulation of spectacles. All that was once lived becomes mere representation . Debords theory of the sectacle is similar to that of Baudrillards theories which concentrate on the ideas of a hyperreality. He considered a photograph to be a replacement for the real object. The lines of reality and non-reality have become so blurred in our society that a photograph can replace the real. Like Debord Baudrillards believed we live in a mediated reality, which prefers the symbol of reality rather than the thing itself. We are constantly bombarded with images form mass media that our own lives are own reality becomes entwined with the images we see. The boundary that should exist between reality and fantasy is erased. A consequence of the age we live in. Images depicting the gruesome nature of war are constantly available on television and in newspapers and magazines; every page turned reveals a new atrocity. We have been flooded with these images for so long that they no longer have an affect on us, instead on inspiring empathy and sympathy we are more passive to them a feeling of indifference. In the mass media if there is a story about celebrities or lifestyle it would surpass gruesome photographs of war. As a society weve almost grown accustomed to these types of images, seeing them everyday. In an essay entitled Photographs of Agony John Berger also argues that society has become immune to images depicting suffering saying that †¦ â€Å"In the last year or so, it has become normal for certain mass circulation newspapers to publish war photographs which earlier would have been suppressed as being too shocking. One might explain this development by arguing that these newspapers have to come to realise that a large section of their readers are now aware of the horrors of war and want to be shown the truth. Alternatively, one might argue that these newspapers believe that their readers have become inured to violent images and so now compete in terms of ever more violent sensationalism.† (ed Wells L, The Phtotgraphy Reader, chapter 27) Berger is questioning the effectiveness of the violent or shocking war photograph arguing that maybe the public have become immune to images of horror and the newspapers are competing to show ever more horrific images in order to gain pubic attention. We look around us and see a world beyond our control. Relying on advanced technologies to conduct war and to replicate it on film and TV has diminished our ability to distinguish between reality and entertainment, turning our experience of war into a mere spectacle. In regarding the Pain of others Susan Sontag Describes societies attraction to violent images†¦Ã¢â‚¬  Everyone knows that what slows down highway traffic going past a horrendous car crash is not only curiosity. It is also for many, the wish to see something gruesome†Ã¢â‚¬ ¦ there does seem to be a modern need fro the consumption of images of suffering. And this abundant supply of imagery has dulled our senses and created a new syndrome of communal inaction, we look around us and see a world beyond our control, which is what Debord was describing in society of the spectacle. In her early book On Photography Susan Sontag writes that â€Å" War and photography now seen insperable†¦Ã¢â‚¬  (pg167) and as war evolves and continues so has the photographers response to the effects of conflict. The Bulky large-format cameras of the 19th century prevented the first war photographers such as roger Fenton from capturing the action of combat instead their photographs concentrated on the aftermath of the battlefields. With the technological advancement of cameras and not needing to haul darkroom equipment with them the first world war photographer could get closer to combat and then during the 2nd world war the introduction of the 35mm camera increased the intimacy of the cameras eye, enabling photographers to become part of the action, in a way the first exponents in the 19 century could never have dreamed. During the Vietnam war photographs could now been seen within days of them being taken, the immediacy making the images relevant and challenging the inevitability of war the viewer was now looking at something which is part of the present, and which carries over to the future. For a century and a half the camera has been witness to events that have shaped and shocked the wor ld, capturing these images forever. We might now live in a world of multi channel television, 24-hour news coverage and instant his on the Internet, but it is the still image that provides the most powerful record of our history, good and bad. The still image seems to hold so much power over us, they last, television is passing and goes by quickly, photography lasts, imprinted on paper and in the mind. War and the effects of warfare have always been explored throughout history in literature, poetry, art, film and photography. Before the first world war the depiction of battles by artists were often of soldiers and generals depicted as heroes, in their uniforms adorned with medals but during the first world war when artists were sent to the front line to record the scene, what they saw there defied their imagination. It soon became clear that the traditional painting couldnt capture the full horror of warfare. The modernist painters began to look at the universal grimness of war, the harsh reality of the world and painted not what they saw but what they felt. For example the artists Paul Nash who served as a solider, portrayed the battlefield in a painting titked Menin Road in 1919, what he depicted was the aftermath of war, a barren scene of an almost alien world the surreal colours a purple blue sky the mutilated bare trees, bursts of smoke rising from the debris strewn ground and blue light filtering through the clouds completely empty apart from four lonely figures in the background. Nash wanted rob warfare of its last shred of glory and its last shine of glamour. Francisco Goyas series of etchings Disasters of War depicts the horrors of the Napoleonic invasion of Spain in 1808 during which French soldiers brutally tortured the Spanish peasants and the Spanish responded with their own acts of cruelty. The works were withdrawn and withheld from publication during Goyas lifetime because of their controversial and disturbing qualities. Susan Sontag writes of Goyas etchings in Regarding the Pain of others, â€Å"†¦Goyas art seems a turning point in the history of moral feelings and of sorrow-as deep, as original, as demanding. With Goya a new standard for responsiveness to suffering enters art Goya was witness to these events during the war, but the etchings depict imagined scenes of the atrocities of violence where the lines between real events and imagined ones blur creating a unique reality that is complimentary yet distinct from the historical realities of war. As the viewer is not lead to believe the images are exact reproduction of act ual events the effect is one of a sincere meditation on the terrifying potential that resides in all humans. The images dont specify who the people are-the soldiers could be French or Spanish, the dead tortured bodies could be those of civilians or soldiers giving the viewer a more open interpretation bringing images to life in a way that relate to personal experience. Goyas images are constantly being revisited looking at Francis Bacon triptych Three Studies for Figures at the Base of a Crucifixion 1944 the twisted screaming distorted creatures depict mans inhumanity to man and capture the fear of the future mood after the second world war and still our mood today, bacon like Goya still has a hold over our imagination, for example the Chapman brothers reconstructed the Disasters of war in 1991 using miniature plastic figurines. Painting and sculpture are clearly viewed as interpretations of the effect and consequences of war, with photography the assumptions is that images are seen as a document they appear real, even when we know photographs can be faked and subject to the photographers view of events. In On Photography Susan Sontag wrote†¦ â€Å"War and photography now seem inseparable.† In On Photography Sontag explains what she saw as the sad state of a society that lived at a more and more voyeuristic distance to the first hand experience of reality. In accordance with this Sontag describes the photographers whose personal concern was apparently with finding out and understanding, were doing no more than satisfying the human thirst for sensation and driving this to extremes by ever more sensational images, until ultimately all feeling was lost. In the book The photograph as contemporary art†¦Ã¢â‚¬ ¦describes the contemporary war photographer†¦ â€Å"The use of medium-and large-format cameras (as opposed to 35mm format), not normally seen at the sites of war and human disaster-not at least, since the mid-nineteenth century-has become a sign that a new breed of photographer is framing the social world in a measured and contemplative manner†¦Ã¢â‚¬  She goes on to say†The subject matter has been different, too; rather than being caught up in the midst of an event, or at close quarters to individual pain and suffering, photogrphers choose to represent what is left behind in the wake of such tradegies, often doing so with style that propses aqualifying pperspective.† It is clear to †¦Contemporary war photographers have in the main taken anti-reportage stance; slowing down image making, remaining out of the hub of action, and arriving after the decisive moment to allow the viewer a more contemplat ive look at war and the effects of war. Using Photomontage Martha Rosler infiltrates our comfort zones and reveals the dangers involved in an illusionary distance often created by the mass media between war and ourselves. By using images from magazines of advertisements combined with military images of soldiers and weaponry she transforms the notion of the safety of a home into one under assault. Her intent is to project the terror and atrocity of war into the comfortable place in which we live. She employs devices that work against the seduction of advertising and consumer imagery, the process of photomontage allows her to expose the gaps between image and reality, and ultimately make the viewer aware of an out of place presence. She addresses the impact of the mass media who according to Debord make the images of horror seem mundane and remote by pointing out the implicit presence of militarism in our daily lives, by juxtaposing popular lifestyle magazine images with stark images of war. The French Photographer Sophie Ristelhuber Photographs depicts the aftermath of war they are usually un peopled with no survivors and no dead, concentrating on the spaces of war rather than its participants, the scars and burns are found on buildings and landscapes rather then the people. Her photographs of the Kuwaiti desert, entitled Fait were made shortly after the end of the first Gulf War. Many of the photographs from this series were taken from a ariel viewpoint This elevated angle creates a distorted abstract view of trenches, tank tracts, bomb craters, blazing oil wells and battlefield detritus. You have to look carefully and closely at the photographs to discover that the lines and tracts objects engulfed by the sand are the results of war scarring the landscape emphasising how vast and sprawling the effects of war can be. Sophie Ristelhueber describes the effects of scale and perspective in her work: †¦.†The constant shift between the infinitely big and the infinitely small may disorientate the spectator. But its a good illustration of our relationship with the world: We have at our disposal modern techniques for seeing everything, apprehending everything, yet in fact we see nothing.† Ristelhueber recently won the Deutsch Borse Photography prize 2010, which included set of images titled eleven blowups, a series of images of huge craters made by bombs In Beirut and Iraq, again the y describes the devastation war leaves behind both on the earth and the body. Paul Seawright photographs the traces of destruction that war leaves behind in a place The solitary places in Seawrights photographs seem to be concealing something they require the viewer to look beneath the surface of the image the isolated barren areas reveal hollows where mines have been cleared or left unexploded, or the subtle rubble of military debris strewn across the desert landscape. The quiet subtlety and blankness of the desert distances them from the spectacle associated with the medias representation of war, there is an unknown tension in the images Seawright generates a view of the futility of war. One of his photographs is almost identical to that of Fentons photograph of the Crimean war depicting empty cannon balls in a valley illustrating the fact that despite its technological advancements war is fundamentally always the same. In his book Hidden Seawright says that he has†¦ â€Å"always been fascinated by the invisible, the unseen, the subject that doesnt eas ily present itself to the camera.† Landlands And Bell were commissioned in 2002 by the imperial war museum to make an artwork in response to a two-week visit to Afghanistan and what they experienced there. Landlands and bells work characteristically focuses on the interconnected relationships linking people and architecture. They say: ‘were totally surrounded by architecture. It is the most tangible record of the way we live because it describes how we relate to socially, culturally and politically. It is the most persistent of the way we live-our aspirations and beliefs.† The result was among other video based works The House of Bin Laden. Presented as an interactive piece similar to a video game the viewer is in control via a joystick to explore a reconstruction of Osama Bin Ladens barren hilltop bunker. The viewer can virtually travel through a bleak set of derelict houses, surrounded by burnt-out cars and debris. Langlands and Bell took thousands of photographs of the house near Jalalabad, The eerie interactive digital exploration of Osama bin Ladens house offers an unsettling experience, and engages with the viewer in a totally new way regarding war photography. The houses surprisingly small and basic. Piles of blankets and clothes are strewn in the rooms elsewhere a single string bed is isolated in a dark corner. Outside there is a series of strangely constructed bunkers and a small mosque. Being in control of looking at the work almost feels like observing a crime scene. The buildings and grounds are absent of any human presence thought signs of people who were once there are constant, although the elusive bin Laden is nowhere to be seen, his presence can still be felt in this mesmerizing and ancient environment. It brings us disturbingly close to him, even as it emphasizes his continuing ability to evade capture. The House of Bin Laden becomes a metaphor for the elusive presence Bin Laden maintains by the very fact of his disappearance. By presenting this piece as an interactive game like simulation Langlands and Bell are actively engaging in the idea of the spectacle by using what is essentially and entertainment based media and allowing the viewer to control their viewer using a joystick, it could be argued that by combing entertainment and unreality with real life situations speaks more to a generation obsessed with mass media. They do not attempt to make the 3d environments look realistic like the photographs they took instead it looks constructed exactly as a computer game would look, angular and flat. I personally experienced this work when I saw the Turner Prize in 2004, and it is clear that their intention was for this piece to be viewed and experienced like a computer game. Violent warfare is sold as entertainment in the form of computer games whose manufactures claim to make them as realistic as possible. Thus reflecting modern societies engagement with entertainment as opposed to real life issues. There seems to be a move in contemporary war photography to a more contemplative and abstract approach, maybe this is as Debord describes because we are use to the violence and horrors the ‘spectacle of war presented in the media, and have become almost immune and unmoved by these images. we can never experience the true horrors of war unless from first hand experience but photographers seem now to be taking the stance of the modernist painters of the first world war who painted what they felt rather than what they saw. Contemporary photographers are interpreting these events rather than documenting them, in a way that enables the viewer a more contemplative approach to the contemporary war photograph.